lecture 2 Flashcards
ethical responsibilities w using animals in research
ensure humane tx and welfare
why are animals used in research
advance science
model to study disease
develop and test therapies
protect safety
what are most research animals used for?
fundamental research, product development
influences in canadian animal research
CCAC, institution, legislation, funding agencies, CALAS (staff), CALAM (vet org)
CCAC
national peer review org
sets guidelines/standards
GAP certificate
from CCAC, required for all places conduction animal research/getting funding from CIHR, NSERC, etc
CCAC review
every 3y
ethics review, compliance w CCAC guidelines, standards
RAWI definition
reportable animal welfare incidents
report within 14d-> significant mortality, threat to welfare
noncompliance to CCAC standards
legislation
in AB-> follow CCAC
canada-> criminal code for abuse, health of animals for disease
3 Rs
replacement, refinement, reduction
replacement
absolute or relative
need to justify model choice
refinement
husbandry to reduce pain, stress
must state ways stress is minimized (training, techniques)
reduction
reduce number of animals used
use stats, max data per animal, blinding
ACC
review protocols and facilities, can suspend studies
who is on an ACC
vet, researchers (with and without animals), animal care tech, student, community member, ACC chair, coordinator
AUP
all planned procedures or activities before starting
reviewed by ACC
what is on an AUP
funding, review, purpose, 3Rs, procedures, animal care, training, endpoints
categories of invasiveness
A- invertebrates
B- little discomfort/stress
C- minor stress, short pain
D- moderate to severe
E- severe pain above tolerance
endpoints
experimental/teaching
humane
AUP review process
review of AUP-> ACC meeting-> application status-> modifications
post approval assurance
ensure study reflects protocol
site visits, review complication, verify training, check research, vet reports
