lecture 2 Flashcards

1
Q

ethical responsibilities w using animals in research

A

ensure humane tx and welfare

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2
Q

why are animals used in research

A

advance science
model to study disease
develop and test therapies
protect safety

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3
Q

what are most research animals used for?

A

fundamental research, product development

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4
Q

influences in canadian animal research

A

CCAC, institution, legislation, funding agencies, CALAS (staff), CALAM (vet org)

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5
Q

CCAC

A

national peer review org
sets guidelines/standards

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6
Q

GAP certificate

A

from CCAC, required for all places conduction animal research/getting funding from CIHR, NSERC, etc

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7
Q

CCAC review

A

every 3y
ethics review, compliance w CCAC guidelines, standards

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8
Q

RAWI definition

A

reportable animal welfare incidents

report within 14d-> significant mortality, threat to welfare
noncompliance to CCAC standards

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9
Q

legislation

A

in AB-> follow CCAC
canada-> criminal code for abuse, health of animals for disease

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10
Q

3 Rs

A

replacement, refinement, reduction

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11
Q

replacement

A

absolute or relative
need to justify model choice

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12
Q

refinement

A

husbandry to reduce pain, stress
must state ways stress is minimized (training, techniques)

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13
Q

reduction

A

reduce number of animals used
use stats, max data per animal, blinding

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14
Q

ACC

A

review protocols and facilities, can suspend studies

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15
Q

who is on an ACC

A

vet, researchers (with and without animals), animal care tech, student, community member, ACC chair, coordinator

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16
Q

AUP

A

all planned procedures or activities before starting
reviewed by ACC

17
Q

what is on an AUP

A

funding, review, purpose, 3Rs, procedures, animal care, training, endpoints

18
Q

categories of invasiveness

A

A- invertebrates
B- little discomfort/stress
C- minor stress, short pain
D- moderate to severe
E- severe pain above tolerance

19
Q

endpoints

A

experimental/teaching
humane

20
Q

AUP review process

A

review of AUP-> ACC meeting-> application status-> modifications

21
Q

post approval assurance

A

ensure study reflects protocol
site visits, review complication, verify training, check research, vet reports