lecture 3

Question 1

specific pathogen colonies

Answer 1

free of pathogens that confound research
strict biosecurity, surviellance

Question 2

bacterial infection prevention

Answer 2

appropriate husbandry, biosecurity

Question 3

bacterial infection treatment

Answer 3

elimination- culling and repopulating, abx (don’t eliminate carriers)

Question 4

bordetella- affects young

Answer 4

mice, rats, guinea pigs, rabbits
young, common in winter
C/S- suppurative rhinitis, dyspnea, infertility, stillbirths, abortion

Question 5

bordetella pathology, dx, tx

Answer 5

fibrinopurulent bronchopneumonia, dead fetus
histo- interstitial pneumonia, cuffing
dx- culture, histo, ELISA< PCR
tx- supportive care, cull

Question 6

flavobacterium bronchophilum, columnare causes, C/S

Answer 6

crowding, poor water quality, transportation
C/S- laboured breathing, hyperemic gills, fin rot, saddle back lesion

Question 7

flavobacterium dx, tx

Answer 7

wet mount gills, fused lamellae, filamentous bacteria, excess mucous

tx- oxytetracycline, antiseptic baths

Question 8

pasteurella multocida transmission, C/S

Answer 8

direct contact, aersol, fomite, vertical

C/S- subclinical infection, rhinitis, conjunctivitis, abscesses otitis media

Question 9

pasteurella pathology, dx, tx

Answer 9

septicemia, bronchopneumonia, pyometra, metritis, arthritis

dx- culture, PCR, serology
tx- enro
prevention- cull carriers

Question 10

strep zooepidemicus guinea pigs

Answer 10

C/S- enlarged LN, exudate, nasal dc, abortions

pathology- bronchopneumonia, lymphadenitis

Question 11

strep zoo dx, tx

Answer 11

dx- culture, PCR
tx- cull

Question 12

citrobacter rodentium C/S, pathology

Answer 12

C/S- d+, rectal prolapse, ruffled fur, stunting (weanlings)

thickened colon, ulceration

Question 13

citrobacter dx, prevention, research implication

Answer 13

dx- pathology, culture, history
prevention- surveillance, decontamination

implications- increased colon sensitivity, immune dysfunction, poor repro

Question 14

tyzzers C/S, pathology

Answer 14

C/S- sudden death, d+, scruffy coat, lethargy, poor BCS
pathology- intestine, liver, heart

Question 15

tyzzers dx, tx, prevention

Answer 15

dx- PCR, serology, histo
prevent- sterile food, control vermin
tx- cull
alters cytokines, zoonotic

Question 16

aeromonas hydrophila and sobria causes, C/S, pathology

Answer 16

poor water conditions- zebrafish and xenopus
C/S- petechial hemorrhage, skin lesions, coelomic distension

pathology- distended coelom, hemorrhage, epidermal ulceration on histo

Question 17

aeromonas dx tx

Answer 17

dx- culture from kidneys
tx- oxytet, nifupirinol, correct husbandry
zoonotic

Question 18

corynebacterium bovis

Answer 18

mice/rats
immunodeficiency, hair loss
C/S- white flakes, alopecia, weight loss
pathology- scaly dermatitis, hyperplasia on histo

Question 19

corynebacterium bovis dx, tx, implications

Answer 19

dx- culture, PCR
tx- tetracyclines, enro, ampi
prevention- surviellance
implications- decreased tumour take

Question 20

mycobacterium (fish TB)

Answer 20

m. chelonae, haemophilum, marinum ingested
C/S- lethargy, emaciation, skin ulceration, distension, hyperemia, skeletal deformity

pathology- small tan nodules in viscera
dx- acid fast bacteria in spleen/kidney, culture, PCR
tx- cull, bleach system
zoonotic

Question 21

staph aureus/xylosus

Answer 21

ubiquitous, aerosol or contact transmission
C/S- dermatitis, abscesses, pododermatitis

pathology- ulcerative inflammation of skin. splendore hoeppli material??? on histo

Question 22

staph dx, tx

Answer 22

dx- culture skin lesion, histo
tx- abx, NT
implications for welfare