Lecture 1 Flashcards
role of LAM vets
provide vet care, diagnostic services, ACC, provide advice on legislations, models, endpoints.
specialized training, research
top 3 research animals used
mice, fish, cattle
benefits of mice as a model
small size, fast repro, docile. well characterized anatomy, genetic, biology. can get genetically manipulated strains.
outbred vs inbred
outbred- mimics diversity of general population (CD1)
inbred- more consistent, fewer animal used (BL6)
mouse biology
open rooted incisors, closed molars
harderian glands behind eye
two compartment stomach w simple intestines (prone to prolapse, coprophagic)
high metabolism, concentrated urine w protein
thermoreg-> no sweat, brown fat
common uses of mice
genetic disease, infectious disease, microbiome, immunology
benefits of rats as a model
small size, short repro cycle, docile, known genetics, similar diseases to humans
outbred/inbred rats
sprague dawley- outbred
fischer- inbred
rat biology
nocturnal
harderian glands
have margo plicatus, cannot v+
no gallbladder
chromodacryorrhea
prophyrin staining from harderian glands
common uses of rats in science
neuroscience, behaviour, preclinical testing
benefits of hamsters as a model
susceptible to infection, cancer, tumours
cheek pouch
metabolic disorders, cardiomyopathy
behaviour
hamster biology
cheek pouches, flank glands
hibernate/torpor
sensitive to steroids, resistant to antihistamines and morphine
benefits of guinea pigs as a model
docile, small
lg bullae->auditory research
resp similar to humans
derm testing (hairless)
guinea pig biology
require vit C
open rooted teeth
absorb all calcium from their diet
fibrocartilaginous pubic symphysis
altricial newborn
have heterophil WBCs
resistant to steroids
benefits of rabbits as a model
diet induced CV disease
lg size (medical device testing)
lg blood volume (immunology)
lg eye (ocular research)
rabbit biology
open rooted teeth
coprophagy
sensitive to high cholesterol
heterophils
R AV valve bicuspid
all calcium from diet absorbed
urine has crystals
benefits of zebrafish as a model
small size, lg numbers
year round spawning, translucent eggs
fully sequenced genome
uses of zebrafish
developmental biology
tissue regeneration
cancer research
zebrafish biology
freshwater, adults sexually dimorphic
mature in 2-4m
african clawed frog benefits
lg embryos, short generation time
can perform gene editing
frog research uses
developmental biology
molecular research
developmental toxicology
african clawed frog biology
have lungs
need vit A
avoid phenol disinfectants
mucous/granular skin glands
seat (drink) patches
