Lecture 1 Flashcards

1
Q

role of LAM vets

A

provide vet care, diagnostic services, ACC, provide advice on legislations, models, endpoints.
specialized training, research

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2
Q

top 3 research animals used

A

mice, fish, cattle

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3
Q

benefits of mice as a model

A

small size, fast repro, docile. well characterized anatomy, genetic, biology. can get genetically manipulated strains.

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4
Q

outbred vs inbred

A

outbred- mimics diversity of general population (CD1)
inbred- more consistent, fewer animal used (BL6)

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5
Q

mouse biology

A

open rooted incisors, closed molars
harderian glands behind eye
two compartment stomach w simple intestines (prone to prolapse, coprophagic)
high metabolism, concentrated urine w protein
thermoreg-> no sweat, brown fat

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6
Q

common uses of mice

A

genetic disease, infectious disease, microbiome, immunology

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7
Q

benefits of rats as a model

A

small size, short repro cycle, docile, known genetics, similar diseases to humans

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8
Q

outbred/inbred rats

A

sprague dawley- outbred
fischer- inbred

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9
Q

rat biology

A

nocturnal
harderian glands
have margo plicatus, cannot v+
no gallbladder

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10
Q

chromodacryorrhea

A

prophyrin staining from harderian glands

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11
Q

common uses of rats in science

A

neuroscience, behaviour, preclinical testing

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12
Q

benefits of hamsters as a model

A

susceptible to infection, cancer, tumours
cheek pouch
metabolic disorders, cardiomyopathy
behaviour

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13
Q

hamster biology

A

cheek pouches, flank glands
hibernate/torpor
sensitive to steroids, resistant to antihistamines and morphine

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14
Q

benefits of guinea pigs as a model

A

docile, small
lg bullae->auditory research
resp similar to humans
derm testing (hairless)

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15
Q

guinea pig biology

A

require vit C
open rooted teeth
absorb all calcium from their diet
fibrocartilaginous pubic symphysis
altricial newborn
have heterophil WBCs
resistant to steroids

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16
Q

benefits of rabbits as a model

A

diet induced CV disease
lg size (medical device testing)
lg blood volume (immunology)
lg eye (ocular research)

17
Q

rabbit biology

A

open rooted teeth
coprophagy
sensitive to high cholesterol
heterophils
R AV valve bicuspid
all calcium from diet absorbed
urine has crystals

18
Q

benefits of zebrafish as a model

A

small size, lg numbers
year round spawning, translucent eggs
fully sequenced genome

19
Q

uses of zebrafish

A

developmental biology
tissue regeneration
cancer research

20
Q

zebrafish biology

A

freshwater, adults sexually dimorphic
mature in 2-4m

21
Q

african clawed frog benefits

A

lg embryos, short generation time
can perform gene editing

22
Q

frog research uses

A

developmental biology
molecular research
developmental toxicology

23
Q

african clawed frog biology

A

have lungs
need vit A
avoid phenol disinfectants
mucous/granular skin glands
seat (drink) patches