Non Hodgkins Lymphoma

Question 1

What are the two types of NHL?

Answer 1

B cell derived = 85%

T cell/NK derived = 15%

Question 2

How does NHL present?

Answer 2

superficial lymphadenopathy - asymmetric, painless, discreet 
B symptoms
oropharyngeal involvement - sore throat
anaemia, neutropenia, thrombocytopenia 
liver and spleen enlargement

Question 3

How is NHL investigated?

Answer 3

whole lymph node biopsy

trucut biopsy of lymph node

Question 4

What is a prognosis marker of NHL?

Answer 4

LDH - increased in rapidly progressing disease

Question 5

How is NHL staged?

Answer 5

same as HL

Question 6

How is HL and NHL treated?

Answer 6

chemo

monoclonal antibodies against tumour cell

Question 7

What is high grade NHL?

Answer 7

immature lymphocytes

Question 8

What is low grade NHL?

Answer 8

mature lymphocytes