Hodgkins Lymphoma Flashcards
1
Q
What is HL?
A
accumulation of malignant lymphocytes in lymph nodes and other lymphoid tissue - MAY spill into blood
2
Q
How is HL differentiated from NHL?
A
HL = Reed-Sternburg cells - neoplastic B cells
3
Q
How does HL present?
A
painless, asymmetrical firm and discreet enlarged lymph nodes - usually cervical B symptoms itch alcohol induced pain splenomehaly mediastinal involvement young patients - normally female
4
Q
What is seen on blood investigation of HL?
A
normochromatic normocytic anaemia
neutrophillia and eosinophillia
increased ESR and CRP
increased LDH
5
Q
How is HL diagnosed?
A
biopsy of affected lymph node
6
Q
How is HL staged?
A
PET + CT
7
Q
What is stage 1 HL?
A
node involvement of one lymph node area
8
Q
What is stage 2 HL?
A
disease involvement of two or more lymph node areas
9
Q
What is stage 3 HL?
A
disease involving lymph nodes above and below the diaphragm
10
Q
What is stage 4 HL?
A
involvement outside the lymph node areas
