Non-Hodgkins Lymphoma

Question 1

Burkitt lymphoma

Answer 1

• B-cell [ t(8;14) ] - c-myc
• Adolescents/young adults
• Starry sky
• EBV
• Endemic (Africa) - jaw lesion
• Sporadic - abdomen/pelvis

Question 2

Diffuse large B-cell lymphoma

Answer 2

• B-cell (most common nHL in adults)
• Sporadic or from Follicular lymphoma
• Older adults, 20% children
• Agressive, enlarging LN or extranodal mass

Question 3

Follicular lymphoma

Answer 3

• B-cell [ t(14;18) ] - BCL-2
• Adults
• Indolent course
• Painless “waxing and waning” LAD
• Nodular, small cells, cleaved nuclei
• Monoclonal K:L ratio, no macros in GC

Question 4

Mantle cell lymphoma

Answer 4

• B-cell [ t(11;14) ] - cyclin-D1
• Older males
• CD20 and CD5+ (CD23 -ve)

Question 5

Marginal Zone lymphoma

Answer 5

• B-cell
• only with chronic inflammation (Hash, Sjog, H.py, gast)
• 3 types: splenic, extranodal (MALToma), nodal

Question 6

Adult T-cell lymphoma

Answer 6

• T-cell [ HTLV-1 ]
• assoc. w/ IVDA
• Cutaneous lesions, lytic bone lesions, hypercalcemia
• Adults
• Japan, W.Africa, Caribbean

Question 7

Mycosis fungoides/

Sezary syndrome

Answer 7

• T-cell [ atypical CD4+ cells with “cerebriform” nuclei ]
• MF = lymphoma
• SS = leukemia
• Adults
• Pautrier microabscess (neoplastic T-cell agg in epidermis)