Cytokines Flashcards
1
Q
IL-1 (aka osteoclast activating factor)
A
By Macros:
- Fever
- Acute inflammation
- Activates endothelial cells to express adhesion molecules
- Induces chemokine secretion to recruit WBCs
2
Q
IL-6
A
By Macros:
- Fever
- Stimulates production of acute-phase proteins
3
Q
IL-8
A
By Macros:
- Neutrophil chemotaxis (major)
4
Q
IL-12
A
By Macros:
- T-cells into Th1 cells
- Activates NK-cells
5
Q
TNF-alpha
A
By Macros:
- Mediates septic shock
- Activates endothelium
- WBC recruitment and vascular leak
- Cachexia in malignancy
- synoviocytes secrete metalloproteinase (cartilage degen)
6
Q
IL-2
A
By all T-cells:
- Growth of helper, cytotoxic and regulatory T cells
- Growth of NK cells
7
Q
IL-3
A
By all T-cells:
- Growth and differentiation of bone marrow stem cells (like GM-CSF)
8
Q
Interferon-gamma (INF-gamma)
A
By Th1 cells: [acts via JAK[dimerization]-STAT pathway]
- Secreted by NK cells in response to IL-12 from macros
- Stimulates macrophages to kill phagocytksed pathogens
- Activates NK cells to kill virus-infected cells
- Increased MHC expression and antigen presentation by all cells
9
Q
IL-4
A
By Th2 cells:
- Differentiation into Th2 cells
- Growth of B cells
- Class switching to IgE and IgG
10
Q
IL-5
A
By Th2 cells:
- Differentiation of B cells
- Class switching to IgA
- Growth and differentiation of eosinophils
11
Q
IL-10
A
By Th2 cells and regulatory T-cells:
- Modulates inflammatory response
- Decreases expression of MHC II and Th1 cytokines
- Inhibits activated macrophages and dendritic cells
[TGF-beta also attenuates the immune response]
