HIV - DRUGS

Question 1

PI’s

Answer 1

-navir

Question 2

Ritonavir

Answer 2

PI that inhibits p-450, thus boosting other drug concentrations (good)

Question 3

PI AE

Answer 3

• Hyperglycemia, N/D, Lipodystrophy, central adiposity (buffalo hump)
• Nephropathy, hematuria (indinavir)

Question 4

PI contraindications

Answer 4

Rifampin (CYP/UGT inducer) - decreasing concentrations of PI

Question 5

NRTI: ABC

Answer 5

Abacavir

Question 6

NRTI: ddl

Answer 6

Didanosine

Question 7

NRTI: FTC

Answer 7

Emtricitabine

Question 8

NRTI: 3TC

Answer 8

Lamivudine

Question 9

NRTI: d4T

Answer 9

Stavudine

Question 10

NRTI: TDF

Answer 10

Tenofovir

- only nucleotide NRTI

Question 11

NRTI: ZDV/AZT

Answer 11

Zidovudine

- general prophylaxis and pregnancy

Question 12

NRTI: adverse effects

Answer 12

• Bone marrow supression (reversed w/ G-CSF + EPO)
• peripheral neuropathy
• lactic acidosis (nucleosides)
• anemia (ZDV)
• pancreatitis (didanosine)
• hypersensitivity rxn (abacavir - assoc. w/ HLA-B*57:01)

Question 13

NNRTI’s

Answer 13

Delavirdine
Efavirenz
Nevirapine

Question 14

NRTI: MOA

Answer 14

3 host phosphorylation –> RT inhibition and chain termination (lacks 3’ OH)

Question 15

NNRTI: MOA

Answer 15

No phosphorylation –> alt. site RT binding and inhibition

Question 16

NNRTI: AE

Answer 16

• Rash and hepatotoxicity
• Vivid dreams and CNS Sx (efavirenz)
• contraindicated in pregnancy (delavirdine and efavirenz)

Question 17

Raltegravir (MOA and AE)

Answer 17

• Reversible inhibition of integrase

- increased creatine kinase

Question 18

Enfuvirtide (MOA and AE)

Answer 18

• binds gp41 (inhibits viral entry)

- skin rxn at injection site

Question 19

Maraviroc

Answer 19

Binds CCR-5 on surface of T-cells/monocytes –> inhibits interaction w/ gp120