Non-Hodgkin's Lymphoma

Question 1

Define Non-Hodgkin’s Lymphoma

Answer 1

All lymphomas without Reed-Sternberg cells

Question 2

What is the most common NHL?

Answer 2

Diffuse large B-cell lymphoma

Question 3

What B symptoms might be present?

Answer 3

Fever, night sweats, weight loss

Question 4

What investigations would you do?

Answer 4

FBC, lactose dehydrogenase, lymph node biopsy, bone marrow biopsy

Question 5

What staging system is used?

Answer 5

Ann Arbor

Question 6

What is Burkitt’s lymphoma?

Answer 6

A childhood disease with characteristic jaw lymphadenopathy

Question 7

What are signs and symptoms?

Answer 7

Fever and sweating, enlarged, rubbery non-tender lymph nodes, B symptoms, GI and skin involvement

Question 8

What would FBC show?

Answer 8

Anaemia, high ESR

Question 9

Is lactose dehydrogenase raised or lowered?

Answer 9

Raised

Question 10

What managements would you start?

Answer 10

Steroids, monoclonal antibodies to CD20, CHOP regimen

Question 11

Give an example of a monoclonal antibody to CD20

Answer 11

Rituximab

Question 12

What does CHOP stand for?

Answer 12

Cyclophosphamide, Hydroxy-daunorubcin, vincristine, prednisolone

Question 13

Where is CD20 found?

Answer 13

Surface of B cells