Chronic Lymphocytic Leukaemia Flashcards
1
Q
What is the commonest leukaemia?
A
CLL
2
Q
What is CLL?
A
Progressive accumulation of a malignant clone of functionally incompetent B cells
3
Q
What are some symptoms in severe cases?
A
Wt loss, sweats, anorexia
4
Q
What is a potential sign?
A
Enlarged, rubbery, non-tender nodes
5
Q
What would you see on a blood film?
A
Small mature lymphocytes, smudge cells
6
Q
When would you consider drugs?
A
If patient is symptomatic
7
Q
What staging system is used and how many stages are there?
A
Rai stages, 5 stages (0-IV)
8
Q
What would you see on a FBC?
A
High WCC with high lymphocytes
9
Q
What therapies are available?
A
Chemotherapy, monoclonal antibodies, targeted therapy
10
Q
Give an example of a monoclonal antibody
A
Rituximab
11
Q
Give an example of a targeted therapy
A
Bruton kinase inhibitors
