Glucose-6-Phosphate Dehydrogenase Deficiency Flashcards
1
Q
What is haemolysis?
A
Premature breakdown of RBCs
2
Q
What two enzyme defects can cause haemolytic anaemia and how are they inherited?
A
Glucose-6-phosphate dehydrogenase deficiency - X linked, Pyruvate kinase deficiency - AR
3
Q
What can be signs and symptoms of G6PD deficiency?
A
Pallor, fatigue, palpitations, SOB, jaundice
4
Q
What would you find on a blood film in G6PD deficiency?
A
Irregularly contracted cells, bite cells, reticulocytosis, G6PD levels low
5
Q
How would you treat G6PD deficiency?
A
Blood transfusion, stop any exacerbating drugs
