Non Hodgkin Lymphoma Flashcards
Tumour derived from
B cells and T cells
No presence of
Reed-Sternberg cells
Mature T cells found in
Paracortex of lymph nodes and circulate in blood
T cell type
CD4 helper
Cd8 cytotoxic
When mutation occurs what happens
Cell is supposed to under go apoptosis but instead becomes neoplastic cell
Which kind of lymphomas likely
Extranodal
Which lymphomas more common
B cell
B cell lymphomas are
More common
Express CD20
Grow at any pace
Most common B cell lymphoma
Diffuse large B cell lymphoma
Aggressive
Burrikit lymphoma
High,y aggressive
Chromosomal translocation
Extra nodal involvement of jaw in Africa
Associated with Epstein bar virus
Outside Africa extranodal involvement of abdomen
Less associated with Ebv
Starry sky appearance under microscope
T cell lymphoma
Adult t c ell lymphoma
Mycosis fungoides - causes patches on the skin that look like a fungal infection
Mycoises fungoides hallmark
CD4 helper cell
Cerebriform nucleus
Looks like a brain
Can cause red itchy skin (sezary syndrome)
Symptoms
Fever
Weight loss
Night sweats
Painless lymphadenopathy
Extranodal symptoms
GI= bowel obstruction
Bone marrow = fatigue, bruising, recurrent infection
Spinal chord= loss of sensation
Diagnosis
Ct scan
Lymph node biopsy
