Chronic Leukemea Flashcards
1
Q
2 types
A
CML =Chronic myeloid leukaemia
CLL= chronic lymphoblastic leukemia
2
Q
In CLL and CML what happens
A
CML- divide too quickly
CLL- don’t die as they should
Leads to too many premature cells
3
Q
Philadelphia translocation means that
A
Forms BCRABL gene
And cell division is always on
4
Q
B cells in CLL Do what
A
Interfere with B cell receptors which should only be signalled in infection
This activates tyrosine kinase
5
Q
Premature B cells show which markers
A
CD23
CD19
CD5
6
Q
Diagnosis ?
A
Technique: blood smear
CML: granulocytes+ monocytes
CLL= smudge cells (broken B cells)
7
Q
Conclusive diagnosis
A
Genetic testing
8
Q
Treatment
A
Tyrosine kinase inhibitor (less effective for CLL)
Chemo
Stem cell transplant
Bone marrow transplant
