Non-Hodgkin Lymphoma Flashcards
Non-Hodgkin Lymphoma (NHL)
Non-Hodgkin Lymphoma (NHL)
- Plasma cells are found in the medulla of lymph
- Plasma cells release antibodies (immunoglobulins) which bind to pathogens
- B cells have CD markers on surface whic can bind to pathogens
- Some B cells form immunoglobulins, others go to lymph medulla to form centroblasts which then proliferate
Non-Hodgkin Lymphoma (NHL)
T cell develeopment starts in thymus fro precursors in bone marrow
Form T helper and T supressor cells
They then circulate in the blood and end up in the paracortex of the lymph
Non-Hodgkin Lymphoma (NHL)
NHL arises from a genetic mutation
B/T cells are supposed to undergo cell destruction after a time (apoptosis)
In NHL they divide uncontrollably, becoming a neoplastic cell
Usually develop in lymphomas ⇒called nodal lymphomas
Can develop in other organs ⇒ called extra nodal lympghomas
Go to GI tract, Bone marrow, spinal cord
Non-Hodgkin Lymphoma (NHL)
Non-Hodgkin B cell Lymphoma
(More Common)
B cell expresses CD20 on the cell surface
Can be:
- INDOLENT
- AGGRESSIVE
- HIGHLY AGGRESSIVE
Types of B cell Lymphoma:
- Diffuse large cell lymphoma
- Follicular lymphoma
Over sxpression of BCL2 gene stops cell death
Non-Hodgkin Lymphoma (NHL)
Non-Hodgkin B cell Lymphoma
Burkitt Lymphoma
Burkitt lymphoma have a starry sky appearance
Non-Hodgkin Lymphoma (NHL)
Non-Hodgkin B cell Lymphoma
Mantle Cell Lymphoma (Aggressive)
Marginal Zone Lymphoma (Indolent)
Lymphoplasmacytic Lymphoma (Indolent)
Non-Hodgkin Lymphoma (NHL)
Non-Hodgkin T cell Lymphoma
Adult T Cell Lymphoma
Mycosis Fungoides
General symptoms of NHL:
- Painless lymphadenopathy
- Fever
- Drenching night sweats
- Weight loss
If extra nodal involvement of:
- GI tract - bowel obs
- Bone marrow - fatigue, bruising, infections
- Spinal cord - loss of sensation in legs
Non-Hodgkin Lymphoma (NHL)
Diagnosis/Treatment
Summary
