Non-hematogenous pigments Flashcards
Albinism
Genetically induced condition where no melanin is produced in the whole body
Vitiligo
An immune mediated attack to melanocytes or keratinocytes leading to depigmented areas in skin or hair
Acquired hypopigmentation
Associated with hormonal imbalances
Local loss of melanocytes due to physical trauma or chemical injury
Due to dietary copper deficiency producing generalised hypopigmentation
Acquired melanosis
Ultraviolet light stimulates increase in melanin production in exposed skin
Congenital melanosis
Occurs when melanocytes don’t disperse evenly during embryonic development
Melanocytic neoplasia
Refers to growths that originate from melanocytes
Carotenes
pigments are present in plants
Fatty change
the abnormal accumulation of triglycerides in parenchymal cells
Increased fat mobilization
Occurs after starvation (especially in obese animals)
With pregnancy toxemia/ ketosis in late gestation ewes carrying twins
With ketosis in high producing dairy cows in early lactation
In animals with diabetes mellitus
Decreased mobilization of fat
Due to abnormal mitochondrial function
Pregnancy toxemia of ewes
Alcoholism in humans
After toxic damage to hepatocytes
Reduced transport of fat
Often due to decreased synthesis of apoprotein
In starvation of protein manipulation
Glycogen
Excessive accumulation of glycogen can occur with certain metabolic abnormalities in skeletal muscle
With glycogen storage disease in various organs and in the liver with diabetes mellitus
Or in dogs with a endocrine disease called hyperadrenocorticism
Proteins
Can accumulate in the proximal renal tubular epithelial cells in animals with severe chronic kidney disease
Amyloid
Is an abnormal substance formed due to misfolded proteins
