non alcoholic liver disease

Question 1

define non alcoholic fatty liver disease

Answer 1

chronic liver disease not due to alcoholism and instead results from fat deposition in the liver

Question 2

what are the risk factors of non alcoholic fatty liver disease?

Answer 2

• obesity
  -poor diet and low exercise
• T2DM
• high cholesterol
• smoking
  -high bp
• drugs
  -middle aged onwards

Question 3

describe the progression of non alcoholic fatty liver disease

Answer 3

1. Hepatosteatosis
   - ( non alcoholic fatty liver)
2. non alcoholic steatohepatitis
3. fibrosis
4. cirrhosis

Question 4

what are the symptoms of non alcoholic fatty liver disease?

Answer 4

• usually asymptomatic and any findings normally found are incidental initially
• if very severe- signs of liver failure, nausea, vomiting, diarrhoea, hepatomegaly

Question 5

how is non alcoholic fatty liver disease diagnosed?

Answer 5

1. bloods
2. imaging
3. biopsy

Question 6

what blood tests would be done to diagnose non alcoholic fatty liver disease? what do they look like?

Answer 6

• deranged LFTS- high PT/INR, low albumin, high bilirubin
• FBC- thrombocytopenia. hyperglycaemia

Question 7

what imaging would be done to diagnose non alcoholic liver disease?

Answer 7

ultrasound abdomen and liver

Question 8

what is the non invasive scoring system used for?

Answer 8

to asses the risk of fibrosis

Question 9

what treatment is done for non alcoholic liver disease?

Answer 9

• lose weight- low BMI
• control RF ( statins, metformin, ACE-i)
• vitamin E

Question 10

what complications are associated with non alcoholic liver disease?

Answer 10

• HE
• ascites
• HCC
• portal HTN
• oesophageal varices