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alcoholic liver disease Flashcards

1
Q

define alcoholic liver disease

A

most common cause of liver failure
- chronic liver disease caused by excess alcohol

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2
Q

what are the risk factors for alcoholic liver disease?

A
  • chronic alcohol
  • obesity
    -smoking
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3
Q

how do you calculate units of alcohol consumed?

A

[strength (ABV) x vol/ml]/
1000

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4
Q

what is the recommended units of alcohol a week?

A

14 a week

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5
Q

describe the progression of alcoholic liver disease

A
  1. steatosis
    - ( undamaged fatty liver)
  2. alcoholic hepatitis
    -( with mallory bodies)
  3. alcoholic cirrhosis
    - (micronodular)
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6
Q

what are the symptoms at an early stage of alcohol liver disease?

A

no symptoms

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7
Q

what are the symptoms at a late stage of alcohol liver disease?

A

chronic liver + alcohol dependency failure symptoms

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8
Q

what are the signs of alcoholic liver disease?

A

hepatomegaly

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9
Q

what questionnaire is used to ask about alcohol dependency?

A

CAGE

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10
Q

what does CAGE stand for?

A

C- cut down
A- annoying people
G- guilt
E- eye opening ( morning drink)

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11
Q

what score in the cage questionnaire would mean dependent on alcohol?

A

> 12 ( or equal to)

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12
Q

how is alcohol liver disease diagnosed?

A
  1. bloods- FBC,LFT,Clotting profile
  2. biopsy
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13
Q

FBC: what would an ALD patient look like

A

macrocytic
non megaloblastic anaemia
low folate

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14
Q

LFT: what would an ALD patient look like

A

High bilirubin
low albumin
high GGT
AST: ALT > 2

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15
Q

CLOTTING PROFILE: what would an ALD patient look like

A

High PT

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16
Q

what would a biopsy tell you?

A

confirm the extent
shows the inflammation, necrosis, mallory cytoplasmic inclusion bodies

17
Q

what are the three types of treatment for ALD?

A
  1. conservative
  2. pharmacological
  3. surgical
18
Q

what does conservative treatment for ALD include?

A

stop alcohol
healthy diet
- give diazepam

19
Q

what does pharmacological treatment for ALD include?

A

short term steroids
- maddreys discriminant value 32+
- B1 + Folate supplements

20
Q

why do you give diazepam for?

A

Delirium tremens - withdrawal symptoms

21
Q

what is the surgical treatment for ALD?

A

Liver transplant

22
Q

what are the 7 complications associated with alcoholic liver disease?

A
  1. pancreatitis
  2. mallory weiss tear
  3. heapatocellular carcinoma
  4. delirium tremens
  5. HE
  6. ascites
  7. Wernicke-Korsakoff syndrome ( a combined b1 deficiency and alcohol withdrawal)
23
Q

what is the treatment for Wernicke-Korsakoff syndrome?

A

iv thiamine

24
Q

what are the symptoms of wernicke Korsakoff?

A

ataxia, nystagmus, encelopathy, low memory, confusion

Liver (21 decks)

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