chronic liver failure Flashcards
define chronic liver failure
progressive liver disease over 6+ months due to repeated liver insults
what are the causes of chronic liver failure?
- ALD ( alcohol)
-NAFLD ( non- alcoholic) - viral - Hep B, C
- Autoimmune
- Metabolic- iron, copper
What are the stages of chronic liver failure?
1.Hepatitis/ Cholestasis
2. Fibrosis- reversible damage
3. Cirrhosis- irreversible
- compensated- some extent of liver function
OR
decompensated
what is decompensated ( ELSF) a huge risk factor for?
hepatocellular carcinomas
what are signs of decompensated (ELSF) ?
- jaundice
- HE
- Coagulopathy
- ascites
- low albumin
what does the child Pugh score assess?
the prognosis and extent of Tx required
what does the child pugh score measure?
bilirubin, ascites presence, serum albumin, PT/INR, Hepatic encelopathy
what are the three classes in the child Pugh score?
A- 100% LY SURVIVAL
B- 80% LY SURVIVAL
C-45% LY SURVIVAL
What does the MELD score used for?
for end stage liver disease
what does the MELD score satisfy?
the severity of ELSD for transplant planning
what are the symptoms of chronic liver failure?
- jaundice
-ascites
-HE - portal hypertension
- oesophageal varices
- caput medusae
-spider naevus - palmar erythema
- gynecomastia
-Dupuytren’s contracture - oedema
- malaise
what is the treatment for chronic liver failure?
-prevent progression - via lifestyle modification
-liver transplant- if decompensated
-manage complications
what is Dupuytren’s contracture?
abnormal thickening of palm
what Is caput medusae?
the appearance of a network of painless, swollen veins around your bellybutton. ( like a palm tree)
what is palmar erythema
reddening in palms
