Non-alcoholic fatty liver disease

Question 1

What is the difference between NAFLD and NASH

Answer 1

NAFLD is lipid accumulation without hepatocyte injury, NASH is lipid accumulation with or without fibrosis and inflammation

Question 2

What is the definition/ diagnosis of NAFLD?

Answer 2

• > 5% hepatocyte contain visible intracellular lipid droplets
• Liver fat:water >5.5%

Question 3

What is the process of liver failure?

Answer 3

Healthy - NAFLD - NASH - Cirrhosis - Hepatocellular carcinoma

Question 4

What is the hallmark feature of NASH?

Answer 4

Insulin resistance

Question 5

What is the pathophysiology of fatty liver disease?

Answer 5

A net gain of fat to the liver

Delivery to removal ratio

Question 6

What is the prevalence of NAFLD in western countries?

Answer 6

20-30%

Question 7

True or false, many patients will know they have NAFLD/ NASH when they come to you

Answer 7

False

Question 8

Is higher volume or high intensity necessary for NAFLD

Answer 8

High volume

Question 9

True or false, individuals meeting moderate levels of exercise had lower chance of NASH developing/ progressing

Answer 9

False, NASH appears to relate to intensity

Question 10

What is the most effective way to reduce liver damage?

Answer 10

Exercise + diet

Question 11

What is a good goal for an EP with someone with NAFLD?

Answer 11

Decrease waist circumference