NMJ pharm

Question 1

selective for what kind of receptor?

Answer 1

motor nicotinic receptor

Question 2

depolarizing NMJ blocker

Answer 2

succinylcholine

Question 3

succinylcholine is what class of NMJ blocker?

Answer 3

depolarizing

Question 4

MOA succinylcholine

Answer 4

strong ACh receptor agonist- produces sustained depolarization and prevents muscle contraction

Question 5

complications of succinylcholine

Answer 5

hyperkalemia, hypercalcemia, malignant hyperthermia

Question 6

nondepolarizing drugs

Answer 6

tubocurarine + ium drugs

Question 7

tubocurarine + ium drugs class of NMJ drugs

Answer 7

nondepolarizing drugs

Question 8

how to reverse nondepolarizing drugs

Answer 8

neostigmine, edrophonium and other cholinesterase inhibitors

Question 9

Reversing succinylcholine?

Answer 9

phase I: no antidote

phase II: cholinesterase inhibitors (neostigmine)

Question 10

must give succinylcholine with in case of cardiac arrhythmia…

Answer 10

atropine

Question 11

Fastest non-depolarizing NM blocker, useful for rapid sequence induction intubation

Answer 11

rocuronium

Question 12

why cant you give non-depolarizing meds orally?

Answer 12

highly polar - don’t cross membranes

Question 13

short acting anticholinesterase

Answer 13

edrophonium

Question 14

medium acting anticholinesterase

Answer 14

neostigmine, physostigmine

Question 15

irreversible cholinesterase MOA

Answer 15

inactivates cholinesterase using phosphorylation

Question 16

anticholinesterase side effects

Answer 16

parasympathetic - secretion of salivary, lacrimal, bonrchial, GIT glands
bradycardia, hypotension, pupilary constriction

Question 17

organophosphates side effects

Answer 17

same as anticholinesterase but also with CNS effects - tremor, anxiety, restlessness, convulsions, respiratory arrest, coma