neurotransmitters + pharm Flashcards
1
Q
acetylcholine site of snythesis
A
nucleus basalis of Meynert
2
Q
Where and with what enzyme is acetylcholine formed?
A
Formed in the nerve terminal using choline acetyltransferase.
3
Q
ACh in Alzheimers?
A
Decreased ACh in Alzheimers
4
Q
Molecule dopamine is synthesized from
A
tyrosine
5
Q
fluoxetine
A
SSRI
6
Q
paroxetine
A
SSRI
7
Q
sertraline
A
SSRI
8
Q
citalopram
A
SSRI
9
Q
venlafaxine
A
SNRI
10
Q
duloxatine
A
SNRI
11
Q
amitriptyline
A
TCA
12
Q
nortrytriptyline
A
TCA
13
Q
imipramine
A
TCA
14
Q
desipramine
A
TCA
15
Q
clomipramine
A
TCA
16
Q
amoxapine
A
TCA
17
Q
doxepin
A
TCA
18
Q
amoxapine
A
TCA
19
Q
tranylcypromine
A
MAOI
20
Q
phenelzine
A
MAOI
21
Q
isocarboxazid
A
MAOI
22
Q
selegiline
A
MAOI
23
Q
bupropion
A
atypical - increases NE and dopamine via unknown mechanism
24
Q
mirtazapine
A
atypical - alpha-2 antagonist (increased release of NE and 5-HT) and potent 5-ht2 receptor antagonist
25
trazodone
atypical - blocks 5HT2 and alpha-1 adrenergic receptors
26
bromocriptine
ergot, dopamine agonist
27
pramipexole
dopamine agonist non-ergot
28
ropinirole
dopamine agonist (non-ergot)
29
amantadine MOA
increases dopamine and may increase dopamine release, also used as an antiviral against influenza A
30
amantadine toxicity
ataxia
31
ataxia is toxicity of what parkinsons drug
amantadine
32
selegiline
selectively inhibits MOA-B which preferentially metabolizes dopamine over NE and serotonin (5 HT) (increases bioavailability of dopamine)
(prevents dopamine breakdown)
33
clinical use of selegiline
adjunctive agent to L-dopa for parkinsons
34
selegiline toxicity
may enhance adverse effects of L-dopa
35
COMT inhibitors
entacapone, tolcapone
36
entacapone, tolcapone
COMT inhibitors
When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents COMT from metabolizing L-DOPA into 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD) in the periphery, which does not easily cross the blood brain barrier (BBB).
37
L-dopa must be co-administered with
carbidopa
38
benztropine MOA
antimuscaranic, curbs excess cholinergic activity
39
benztropine affects what symptoms
imrpoves muscle rigidity and tremor but has little effect on bradykinesia
40
L-dopa MOA
increases amount of dopamine in brain, can cross BBB (unlike dopamine)
41
L-dopa is converted to dopamine using which enzyme?
dopa decarboxylase in the CNS
42
What is carbidopa
dopa decarboxylase in the periphery, used to increase bioavailability of l-dopa and to limit peripheral side effects
43
clinical use of l-dopa and carbidopa?
parkinson's disease
44
l-dopa/carbidopa toxicity
arrythmias from increased peripheral formation of catecholamines. long-term use can lead to dyskinesia following administration, akinesia between doses
45
name the drug that causes the following toxicity: arrythmias from increased peripheral formation of catecholamines. long-term use can lead to dyskinesia following administration, akinesia between doses
l-dopa/carbidopa
