Nm agonists and blockers

Question 1

Nm (cholinergic) agonists: 3

Answer 1

succinylcholine
acetylcholine
nicotine

Question 2

mimic role of acetylcholine

Answer 2

Nm agonists (rest and digest; parasympathetic)

Question 3

D-tubocurarine
Cistatracurium
Pancuronium
Vecuronium

Answer 3

Nm blockers

Question 4

what 2 drugs together are used to treat nerve gas and organophosphate poisoning

Answer 4

Atropine and Pralidoxime

Question 5

2 drugs that were given to soldiers to help prevent negative effects from nerve gases (paradoxical prophylaxis b/c these 2 are also AChE inhibitors)

Answer 5

pyridostigmine or physostigmine

Question 6

enzyme regenerator (AChE)

Answer 6

pralidoxime

Question 7

pyridostigmine and physostigmine only occupy half of the AChE’s in the whole body; so half are still open for nerve gas to attack; and when that happens- what do you do

Answer 7

stop treatment (remove the 2 inhibitors), so then while half of the AChE’s are inhibited by nerve gas, the other half are now available to sustain life

Question 8

“perfect example” of drug-receptor theory: dosing the drug perfectly to only occupy half of receptors

Answer 8

pyridostigmine and physostigmine in war