Adrenergic Receptors and Effects

Question 1

VSMC skin and splanchnic receptor and G protein

Answer 1

receptor: alpha1
G-protein: Gq

Question 2

effect of alpha1 and Gq activation

Answer 2

contraction (vasoconstriction)

Question 3

neurons and platelets receptor and G protein

Answer 3

receptor: alpha2
G-protein: Gi

Question 4

effect of alpha 2 and Gi activation

Answer 4

decrease NE release
platelet aggregation

Question 5

SA and AV nodes
cardiomyocytes
kidney juxtaglomerular cells receptor and G protein

Answer 5

receptor: beta1
G-protein: Gs

Question 6

effect of beta1 and Gs activation

Answer 6

heart contraction/conduction
renin secretion

Question 7

VSMC (sk m., brain, coronary, hepatic arteries) receptor and G-protein

Answer 7

receptor: beta2
G-protein: Gs

Question 8

effect of beta2 and Gs activation

Answer 8

vasodilation
bronchodilation

Question 9

adipose tissue receptor and G-protein

Answer 9

receptor: beta3
G-protein: Gs

Question 10

effect of beta3 and Gs activation

Answer 10

lipolysis (activates HSL)

Question 11

VSMC (renal) receptor and G-protein

Answer 11

receptor: D1
G-protein: Gs

Question 12

effect of D1 and Gs activation

Answer 12

vasodilation

Question 13

alpha 2 agonists that decrease sympathetic outflow

Answer 13

clonidine
alpha-methyldopa