Autonomic Diseases and Drugs Flashcards
this happens when the systolic BP is greater than or equal to 20 mm Hg less upon standing
orthostatic hypotension
this happens when the diastolic BP is greater than or equal to 10 mm Hg less upon standing
orthostatic hypotension
tx for orthostatic hypotension
medications to increase bp
2 drugs used to treat orthostatic hypotension (increase bp)
midodrine
droxidopa
what does the convergence of interneurons in spinal cord do to visceral pain
it confuses the brain and it doesn’t know a specific location the pain is coming from so it is referred pain
what kind of disorder is multiple system atrophy
autonomic disorder
molecular mimicry (autonomic disorder) that mediates demyelination of axon in peripheral nerves
GBS
A-block drug used as an antidote for epinephrine that happens before pheochromocytoma surgery
phentolamine
beta-1 agonist that treats septic shock/cardiogenic shock (treats low bp)
Dobutamine
this NT produces bradycardia at M2
Ach
this M-blocker produces tachycardia
Atropine
B1 blocker that treats tachyarrhythmia
metoprolol
Yes or No: is there parasympathetic innervation of VSMC (vascular)
No
what in plasma can produce vasodilation via M3 and release of NO
Ach
B2 agonist used to treat asthma
albuterol
bronchoconstriction receptor
M3
bronchodilation receptor
B2
what treats asthma
M3-blocker
B2 agonists
D1 (Gs) has what effect on the kidneys
dilates renal blood vessels
A2 agonists that decrease NE release and lower bp
clonidine
alpha-methyldopa
when M3 predominates, what happens to pupil
constricts
when A1 predominates, what happens to pupil
dilates
syndrome due to loss of sympathetics
sx’s: ptosis, miosis, enophthalmos, facial anhidrosis
Horner Syndrome
what are all of the receptors that work on bladder
Nn, Nm, M3, A1, B3
what does Nitric Oxide (NO) do to control of erection
dilates and erects
MoA of both NO and Sildenafil leading to erection
both allow increase in cGMP (relaxation and dilation leading to erection)
when this is not phosphorylated, it is bound to SERCA and prevents Ca2+ from entering SR
Phospholambin
what disinhibits SERCA and allows Ca2+ to come back in SR and then later be released by RyR to cause contraction of muscle
when PKA phosphorylates Phospholamban
