Nitroglycerine

Question 1

What class of medication is Nitroglycerine?

Answer 1

Nitrate

Question 2

What is the MOA of Nitroglycerine?

Answer 2

Nitrates are potent vasodilators that increase blood flow to coronary arteries and decrease workload by dilating peripheral vasculature and reducing preload.

Question 3

What is the onset time for Nitroglycerine?

Answer 3

1-3 minutes SL

Question 4

What is the duration time for Nitroglycerine?

Answer 4

Peak: 5-10 minutes

Question 5

What are the indications for giving Nitroglycerine?

Answer 5

Chest pain associated with ACS and Acute pulmonary edema (unless accompanied by hypotension)
Also a first-line therapy for acute CHF

Question 6

What are the contraindications for giving Nitroglycerine?

Answer 6

Hypotension (systolic below 90mmHg), use of phosphodiesterase 5 inhibitors (ED drugs)

Question 7

What is the trade name of Nitroglycerine?

Answer 7

Nitrostat

Question 8

What is the dose of Nitroglycerine given?

Answer 8

0.4mg
May repeat dose every 5 minutes as long as BP is greater than 90 systolic (up to 3 doses)

Question 9

By which route is Nitroglycerine given?

Answer 9

Sublingual