Epinepherine

Question 1

What class of medication is Epinephrine?

Answer 1

Sympathomimetic

Question 2

What is the MOA of Epinephrine?

Answer 2

Binds to Alpha 1 and Beta 2 adrenergic receptor sites causing vasoconstriction, increased HR, and increased force of contraction as well as bronchiolar smooth muscle relaxation

Question 3

What are the indications for giving Epinephrine?

Answer 3

Cardiac Arrest, severe anaphylaxis, severe reactive airway disease.
(symptomatic bradycardia refractory to Atropine)

Question 4

What is the onset time for Epinephrine?

Answer 4

Immediate (<2 minutes)

Question 5

What is the duration time for Epinephrine?

Answer 5

Several minutes

Question 6

What are the contraindications for giving Epinephrine?

Answer 6

use with caution if patient has cardiovascular disease or hypotension
Epi 1:10000 in patients who don’t require CPR

Question 7

What are the side effects of Epinephrine?

Answer 7

Palpitations, tachycardia, anxiety, nausea, vomiting
May cause chest pain, or myocardial ischemia

Question 8

What dose of Epinephrine is given?

Answer 8

Anaphylaxis: 0.3-0.5mg of Epi 1:1000 (repeat by protocol)
Cardiac Arrest: 1mg of Epi 1:10,000 IV every 3-5 minutes

Question 9

By which route is Epinephrine given?

Answer 9

Anaphylaxis: IM
Cardiac Arrest: IV or IO