NHP DNA Viruses Flashcards
What is the family and genus for Monkeypox
Family: Poxviridae, Genus: Orthopoxvirus
Vaccination against this virus confers immunity to monkeypox in most cases
smallpox
T or F, Monkeypox is zoonotic
True. A 2003 outbreak from Prairie dogs that acquired it from gambian pouched rat
Lesions of Monkeypox include vesicular exanthema on the hands, feet and face and can also involve the___________
Respiratory Tract where it causes a hemorrhagic necrosis
This orthopoxvirus was eradicated through intensive vaccination programs in the 1970s
Variola (smallpox)
_____ is the live attenuated Orthopoxvirus used in the small pox vaccine
Vaccinia
What is typical histologically of a pox virus infection
Eosinophilic intracytoplasmic inclusions
What is the typical appearance of a pox virus on electron microscopy
“dumbbell” appearance to viral particles
T or F, Cowpox is Zoonotic
True
what species is resistant to the pox virus, Yaba Monkey Tumor Virus
New World Primates
What is the main reservoir for Monkeypox
African squirrel species
How is monkeypox spread
aerosol, direct contact and biting insects
Monkey pox viremia occurs how many days post infection
3-4days
The classic pox lesion of Monkeypox occurs ____ days post infection
6-7
What type of facility do you need for colony management of monkeypox
ABSL3; BSL2 facility with BSL3 practices
What species have a natural infection to Yaba Virus
Macaques and baboons
Yaba monkey tumor virus and yaba-like disease virus belong to what genus
Yatapoxvirus
What does the Yaba virus infect
histiocytes
T or F, Yaba Virus is zoonotic
True
What are the clinical signs of Yaba Virus
Multiple SQ masses called “pseudotomors” that resolve in 1-2 months. Baboons get oral masses
what virus occurs as a common, latent and typically asymptomatic infection in Asian macaques, but causes ascending paralysis and has a high fatality rate in humans
Macacine herpesvirus 1, Herpes B Virus
How is Herpes B virus transmitted
sexual or biting behavior and by fomites
What are clinical signs of Herpes B Virus
Usually subclinical, lesions included conjunctivitis, vesicles/ulcers on oral and genital mucosa
Where does Herpes B establish latency
Trigeminal and lumbosacral sensory ganglia
You should assume that all macaques and their products are McHV-1 positive
True
