New CNS Flashcards
Antipsychotic Drugs
Typical 3
Atypical 2
- Typical
- Phothiazone
- Haloperidol
- Thiothizene
- Atypical
- Clozapine
- Olanzapine
Antipsychotic Drugs
MoA
3
- Dopamine antagonist
- Block dopamine D2 receptors in doparnergic pathways
- Atypical can also block 5HT 2 receptors
Antipsychotic Drugs
Side effects
- Extrapyramidal Motor Effects
- Neuroleptic Malignant Syndrome
Unipolar antidepressants classes
- Monoamine Uptake inhibitors
- TCA
- SSRI
- SNRI
- NE reuptake inhibitors
- Monoamine Oxidase Inhibitors
- Monoamine receptor antagonists
Monoamine Uptake Inhibitors
4 classes
- NE and 5HT
- TCA
- Amitriptyline
- SSRI (Serotonin selective)
- Fluoxetine (prozac, most commonly rx bc few side effects)
- SNRI (Mixed 5HT and NE)
- Venlafaxine
- Duloxetine
- NE reuptake inhibitors
- Bupropion
MAOI
Phenelzine
Dont use w/ other anti-dep or autonomic drugs that release serotonin or catecholamines
Monoamine Receptor Antagonists
1
Mirtazapine
Block alpha-2 adrenergic receptors
Trazodone
MoA 2
- Anti-depressant
- Potentiates 5HT activity
- Blocks alpha-2 adrenergic receptors
Bipolar Antidepressants
3
- Lithium
- Valporate- antiepileptic
- Olanzapine- antipsychotic
Sedative Hypnotics
9
- Benzodiazepines
- Barbiturates
- Chloral hydrate
- Zolpidem
- Buspirone
- Baclofen
- Diphenyhydramine
- Ethanol
- Flumazenil
Benzodiazepines and Barbiturates
MoA
Enhance effect of GABA on GABA-A receptors
Barbiturates Subclasses and duration of acting3
- Long acting
- Phenobarbital
- Intermediate acting
- Pentobabarbital
- Short acting
- Thiopental
Benzodiazepines half lives 6
- Triazolam 1.5 hrs
- Midazolam 4
- Oxazepam 8
- Lorazepam 14
- Diazepam 48-100
- Flurazepam 100
Chloral Hydrate
MoA
used for 2
- Sim MoA to benzo
- Short acting sleep inducer
- COnsious sedation
Zolpidem
acts on
tx
GABA-A receptor
Insomia
Buspirone
MoA
tx
Partial agonist 5HT1A (NOT GABA)
Anxiety
Baclofen
MoA
tx2
Agonist GABA-B
Muscle relaxant
Trigeminal Neuralgia
Diphenyhydramine
MoA
used for
Block H1 receptors
Sedation
Ethanol
MoA
used for
GABA-A
Sedation
Flumazenil
MoA
Used for
GABA-A Benzo receptor antagonist
Reverse sedation from benzo
MoA of Antiepileptics
4
- Na channel antagonists
- Ca channel antagonists
- Glutamate receptor antagonists
- AMPA, NMDA
- Cl channel agonists
Antiepileptic drugs 7
- Phenobarbital
- Phenytoin
- Primidone
- Carbamazepine
- Gabapentin
- Valporate
- Ethosuximide
Phenobarbital
- GABA-A r modulator
- antiepileptic
- Benzidiazepine
Phenytoin
- ANtiepi
- Na antagonist
- Someti
