New CNS Flashcards
1
Q
Antipsychotic Drugs
Typical 3
Atypical 2
A
- Typical
- Phothiazone
- Haloperidol
- Thiothizene
- Atypical
- Clozapine
- Olanzapine
2
Q
Antipsychotic Drugs
MoA
3
A
- Dopamine antagonist
- Block dopamine D2 receptors in doparnergic pathways
- Atypical can also block 5HT 2 receptors
3
Q
Antipsychotic Drugs
Side effects
A
- Extrapyramidal Motor Effects
- Neuroleptic Malignant Syndrome
4
Q
Unipolar antidepressants classes
A
- Monoamine Uptake inhibitors
- TCA
- SSRI
- SNRI
- NE reuptake inhibitors
- Monoamine Oxidase Inhibitors
- Monoamine receptor antagonists
5
Q
Monoamine Uptake Inhibitors
4 classes
A
- NE and 5HT
- TCA
- Amitriptyline
- SSRI (Serotonin selective)
- Fluoxetine (prozac, most commonly rx bc few side effects)
- SNRI (Mixed 5HT and NE)
- Venlafaxine
- Duloxetine
- NE reuptake inhibitors
- Bupropion
6
Q
MAOI
A
Phenelzine
Dont use w/ other anti-dep or autonomic drugs that release serotonin or catecholamines
7
Q
Monoamine Receptor Antagonists
1
A
Mirtazapine
Block alpha-2 adrenergic receptors
8
Q
Trazodone
MoA 2
A
- Anti-depressant
- Potentiates 5HT activity
- Blocks alpha-2 adrenergic receptors
9
Q
Bipolar Antidepressants
3
A
- Lithium
- Valporate- antiepileptic
- Olanzapine- antipsychotic
10
Q
Sedative Hypnotics
9
A
- Benzodiazepines
- Barbiturates
- Chloral hydrate
- Zolpidem
- Buspirone
- Baclofen
- Diphenyhydramine
- Ethanol
- Flumazenil
11
Q
Benzodiazepines and Barbiturates
MoA
A
Enhance effect of GABA on GABA-A receptors
12
Q
Barbiturates Subclasses and duration of acting3
A
- Long acting
- Phenobarbital
- Intermediate acting
- Pentobabarbital
- Short acting
- Thiopental
13
Q
Benzodiazepines half lives 6
A
- Triazolam 1.5 hrs
- Midazolam 4
- Oxazepam 8
- Lorazepam 14
- Diazepam 48-100
- Flurazepam 100
14
Q
Chloral Hydrate
MoA
used for 2
A
- Sim MoA to benzo
- Short acting sleep inducer
- COnsious sedation
15
Q
Zolpidem
acts on
tx
A
GABA-A receptor
Insomia
