Anticoagulants Flashcards
1
Q
Warfarin
MoA
Antidote
A
- Inhibits Vitamin K dependent synthesis of factors
- II prothrombin
- VII proconvertin
- IX
- X
- Antidote- Vitamin K (phytonadione)
2
Q
Heparin
MoA
Antidote
A
- Stimulates antithrombin III
- Blocks action of Xa, IIa thrombin
- Imediate
- Antidote protamine
3
Q
Low Molecular Weight Heparins
MoA
Antidote 3 ex
A
- Stimulate antithrombin III
- Blocks Xa
- Immediate
- Protamine partially antagonize
- Enoxaparin
- Dlateparin
- Tinzaparin
4
Q
Fondaparimex
MoA
Antidote
A
- Binds antithrombin III
- Blocks action of Xa
- Protamine will NOT antagonizw
5
Q
Direct Thrombin Inhibitors
5
A
- Lepirudin
- Bivalirudin
- Argatroban
- Dabigatran
- Rivaroxban
- Protamine will NOT antagonize
6
Q
Antiplatelet Drugs
2 how
A
- Aspirin cox inhibitor
- Dipyramidole phosphodiesterase inhibitor
7
Q
Clot busters- Plasminogen activators
used to
A
- Used to stimulate fibrinolysis and break down clots
- Alteplase (tissue plasminogen activator)
- tPA variants: Tenecteplase Reteplase
- Streptokinase
8
Q
Procoagulants
what they do
1 ex
A
- Plasminogen inhibitior
- Inhibits clot breakdown fibrinolysis
- Aminocaproic acid
