Antihistamines Flashcards
1
Q
First generation antihistamines
able to
3 ex and what they tx
A
- Cross BBB–> sedative
- Diphenyhydramine
- Promethazine
- entiemetic
- Hydroxyzine
- Antipuritic (anti-itch)
2
Q
Second generation antihistamines
do not
3 ex
risk
A
- DO NOT cros BBB
- Fexofenadine
- Loratadine
- Cetirizine
- SOme cardiac arrythmias risk with high doses
3
Q
H2 antagonists
A
- Cimetidine
- tx GERD, ulcers, dyspepsia
4
Q
Cyclophosphamide
class
A
- Alkylating agent
- Most widely spread
- Kills rapid prolif cells and non
- intrastrand DNA cross linking
5
Q
Methotrexate
class and sub class
A
- Antimetabolite
- Folate antagonists
- Most widely used chemotherapeutic
- Leucovorin used to rescue normal cells
6
Q
Base analogs
subclass of
6 ex
moa
A
- Antimetabolite
- 5-flurouracil, Cytarabine, 6-Mercaptopurine, 6-Thioguanine, Pentostatin, Azathioprine
- Interferes with copying DNA
7
Q
Cytotoxic AB
2 ex (1 has 2 names)
moa
often tx
A
- Doxorubicin (Adriamycin)
- Topoisomerase II inhibitors
- inhibits DNA rep
- Bleomycin
- Squamous cell tumors
- single strand breaks
8
Q
Plant derivatives
ex
moa
tx 2 cancers
A
Paclitaxel (Taxol)
Inhibits mitosis (microtubule assembly)
Breast and ovarian
9
Q
Hormones
1 ex
type of drug-moa
for
mediates
A
Prednisone
Glucocorticoid- inhibits lymphocyte proliferation
Mediates nausea
10
Q
Hormone anatagonist
1 ex
moa
tx
A
Tamoxifen
Estrogen Receptor antagonist
Breast cancer
11
Q
Monoclonal AB
ex
blocks
A
Bevacizumab (Avastin)
blocks angiogenesis
12
Q
Protein Kinase Inhibitors
ex with 2 names
inhibits
A
- Imatinib (Gleevec)
- inhibits Bcr/Abl kinase
13
Q
Management for side effects
A
- Ondansetron
- Emesis
- Myelosuppression
- Erythropoietin: RBC
- Filgastrim- diff of hematopoietic drugs
