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Cardiology > Neurotransmitters > Flashcards

Neurotransmitters Flashcards

1
Q

Area of concentration of Acetylcholine?

A
  1. Autonomic ganglia
  2. NMJ
  3. Caudate nucleus and putamen
  4. Basal nucleus of Meynert (basal forebrain)
  5. Autonomic ganglia and Parasympathetic neurons
  6. Motor nuclei of cranial nerves
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2
Q

Functions/clinicals applications of Ach?

A

Motor function: Myasthenia, surgical muscle relaxation
Memory: Alzheimers/ALzheimer’s Rx
Autnomic function: Organophosphate poisoning, autonimic drugs

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3
Q

Receptors for Ach

A

Nicotinic: Excitory

Muscarnic metabotropic: Excitotry and inhibitory

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4
Q

Area of concentration of glutamate?

A

Everywhere: Spinal cord, brain stem, cerebellum, hippocampus, cerebral cortex

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5
Q

Functions/clinical applications of Glutamate

A

Excitation of cognitive, motor and sensory function: Rx for ALS

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6
Q

Receptors for Glutamate?

A

NMDA (Ca2+): Excitatory ionotropic
AMPA (Na+): Excitotary ionotropic
Kainate (Na+): Excitatory ionotropic
Metabotropic (Ca2+): Excitatory

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7
Q

Area of concentration for GABA?

A

Everywhere: Cerebellum, hippocampus, cerebral cortex, basal ganglia, interneurons of CNS

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8
Q

Functions/clinical applications of GABA?

A

Inhibition of cognitive, motor, and sensory funcrtion: Anxiety/anxiety rx, Drugs of abuse

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9
Q

Receptors for GABA?

A

GABAa: Ionotropic (Cl-) Inhibitory
GABAb: Metabotropic inhibitory

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10
Q

Areas of concentration for Glycine?

A

Spinal cord/interneurons of spinal cord

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11
Q

Functions/clinical applications of Glycine?

A

Spinal cord inhibition, spasticity Rx

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12
Q

Receptors for glycine?

A

Ionotropic (Cl-): Inhibitory

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13
Q

Areas of concentration for Serotonin?

A

Pineal gland, raphe nucleus of pons

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14
Q

Functions/clinical applications of serotonin?

A

Limbic function, depression/depression rx, migraine Rx, sleep regulation

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15
Q

Receptors for serotonin?

A

5HT-3: Ionotropic (Na and K)-excitotry

5HT1-7: Metabotropic, both excitotry and inhibitory

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16
Q

Areas of concentration for norepinephrine?

A

Sympathetic nervous system, locus ceruleus (pons), lateral tegmentum, (Whole brainstem)

17
Q

Functions/clinical applications of norepinephrine?

A

Limbic function: Anxiety/anxiety rx, Arousal/attention, autonomic function: CV Drugs

18
Q

Receptors for norepinephrine?

A

a1: Excitotary
a2: Inhibitory
B1: Excitotry
B2: Inhibitory

19
Q

Areas of concentration for dopamine?

A

Hypothalamus, midbrain substantia nigra

20
Q

Functions/clinical applications of dopamine?

A

Basal ganglia function: Parkinsons/Parkinson’s Rx, psychosis/psychosis Rx, addiction

21
Q

Receptors for dopamine?

A

D1: Ionotropic (K+/Ca2+) and metabotropic: Excitatory
D2: Ionotropic (K+/Ca2+) and metabotropic: Inhibitory

Cardiology (18 decks)

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