Autonomic Drugs Flashcards by John Encarnacion

The parasympathetic system causes which of the following properties: Secretion, SM contraction, SM relaxation, SA/AV node

Positively stimulates Secretion and SM contraction

Negatively affects/inhibits SA/AV node

How well did you know this?

Not at all

Perfectly

The sympathetic system affects which of the following properties: Secretion, SM contraction, SM relaxation, SA/AV node

Positively stimulates SM contraction, SM relaxation, SA/AV node

How well did you know this?

Not at all

Perfectly

What are some of the sympathetic receptors?

a1, a2, B1, B2

How well did you know this?

Not at all

Perfectly

What are some of the parasympathetic receptors?

M2 and M3

How well did you know this?

Not at all

Perfectly

What are the PARAsympathetic receptors for the eye, salivary glands, heart, lungs, stomach, bladder?

Eye: M3
Salivary Glands: M3
Heart: M2
Lungs: M3
Stomach: M3
Bladder: M3

How well did you know this?

Not at all

Perfectly

What are the SYMpathetic receptors for the eye, salivary glands, heart, lungs, stomach, bladder?

Eye: a1, B2
Salivary Glands: B2
Heart: B1
Lungs: B2
Stomach: B2
Bladder: a1, B2

How well did you know this?

Not at all

Perfectly

M3 receptor stimulation has what effects on Secretion, SM contraction, SM relaxation, SA/AV node

Secretion: Stimulates
SM Contraction: Stimulates
SM relaxation: No effect
SA/AV node: No effect

How well did you know this?

Not at all

Perfectly

M2 receptor stimulation has what effects on Secretion, SM contraction, SM relaxation, SA/AV node

Secretion: No effect
SM Contraction: No effect
SM relaxation: No effect
SA/AV node: Inhibits

How well did you know this?

Not at all

Perfectly

a1 receptor stimulation has what effects on Secretion, SM contraction, SM relaxation, SA/AV node

Secretion: No effect
SM Contraction: Stimulates
SM relaxation: No effect
SA/AV node: No effect

How well did you know this?

Not at all

Perfectly

a2 receptor stimulation has what effects on Secretion, SM contraction, SM relaxation, SA/AV node

Secretion: No effect
SM Contraction: stimulates?
SM relaxation: No effect
SA/AV node: No effect

How well did you know this?

Not at all

Perfectly

B1 receptor stimulation has what effects on Secretion, SM contraction, SM relaxation, SA/AV node

Secretion: No effect
SM Contraction: No effect
SM relaxation: No effect
SA/AV node: Stimulates

How well did you know this?

Not at all

Perfectly

B2 receptor stimulation has what effects on Secretion, SM contraction, SM relaxation, SA/AV node

Secretion: No effect
SM Contraction: No effect
SM relaxation: Stimulates
SA/AV node: No effect

How well did you know this?

Not at all

Perfectly

a1, a2, B1, B2 stimulates which type of G-protein?

a1: Gq
a2: Gi
B1: Gs
B2: Gs

How well did you know this?

Not at all

Perfectly

M2 and M3 stimulates which type of G-protein?

M2: Gi
M3: Gq

How well did you know this?

Not at all

Perfectly

Atropine and Glycopyrrolate act on which receptor/? Are they agonists or antagonists?

M2 antagonists, thus increasing cardiac output/HR

How well did you know this?

Not at all

Perfectly

Dobutamine and isoproternol are what type of drugs?

B1 agonists, thus increasing cardiac output/contractility

How well did you know this?

Not at all

Perfectly

Metoprolol, carvedilol, and nadolol are what type of drug?

B-1 antagonists,thus decreasing cardiac output

How well did you know this?

Not at all

Perfectly

M3 activation on the lungs causes bronchoconstriction or bronchodilation?

bronchoconstriction

B2 activation on the lungs causes bronchoconstriction or bronchodilation

bronchodilation

Methacholine is what kind of drug?

M3 agonist, thus causing bronchoconstriction

Ipratropium, tiotropium,, glycopyrrolate are what type of drug?

M3 antagonists, thus causing bronchodilation

Albulterol, salmeterol, epinephrine are what type of drugs?

B2 agonists, thus causing bronchodilation

Detrusor muscle contraction is caused by stimulation of which receptor?

M3, thus promoting urination

Detrusor relaxation is caused by stimulation of which receptor?

B2, thus inhibiting urination

Urethral contraction is caused by which receptor?

a1, thus inhibiting urination

Bethanachol is what kind of drug?

M3 agonists, thus promoting urination

Oxybutynin, solifenacin, tolterodine is what kind of drug?

M3 antagonists, thus inhibiting urination

terazosin, doxazosin, and tamsulosin are what kind of drug?

a1 antagonists, thus promoting urination

Stimulation of the M3 receptor would have what effect on the GI system?

It would induce SM contraction thus promoting digestion

Stimulation of the B2 receptor would have what effect on the GI system?

It would induce SM relaxation thus inhibting digestion

Dicyclomine and Hyocyamine are what type of drugs?

M3 antagonists, thus reducing peristalsis

Stimulation of the M3 receptor has what effect on saliva?

Causes watery saliva secretion

Stimulation of the B2 has what effect on saliva?

Thick saliva secretion

Pilocarpine is what kind of drug?

M3 agonist, thus promoting watery saliva secretion

Glycopyrrolate is what kind of drug?

M3 antagonist, thus causing THICK saliva secretion

Stimulation of the a1 receptor has what effect on the eyes?

Affects the Dilator muscle, thus causing smooth muscle contraction leading to more light in the eyes

Stimulation of the M3 receptor has what effect on the eyes?

Affects the constrictor muscle, thus causing contraction of the constrictor muscle leading to less light in the eyes

Atropine is what kind of drug? and effects the eyes how?

M3 antagonists, thus leading to pupil dilation (inhibits the constrictor muscle)

Carbachol is what kind of drug? and has what effect on the eyes

M3 agaonist, thus promoting pupil constriction via constrictor muscle

Stimulation of M3 has what effect on the uterus?

Induces contractions

Stimulation of B2 has what effect on the uterus?

Causes relaxation

Terbutaline is what kind of drug?

B2 agonist, thus causing uterine relaxation. Can be used to prolong pregnancy if baby is coming out too early

Midronine affects vasculature in what mechanism?

a1 agonist, thus increasing BP (vasoconstriction)

Prazosin, terazosin, doxazosin affect vasculature in what mechanism?

a1 antagonist, thus decreasing BP (vasodilation)