ACS 1 Flashcards
What are some of the endogenous anti-thrombotics that prevent spontaneous thrombosis and arterial occlusion?
- Antithrombin 3: Plasma protein that binds irreversible to thrombin and other clotting factors; increased effectiveness with heparin
- Protein C and S- Degrades factors Va and VIIIa
- Tissue factor pathway inhibitor: Plasma serine protease inhibitor activated by factor Xa; inhibits coagulation via the extrinsic pathway
What are other endogenous factors involved in ACS?
- TPA: Secreted by endothelial cells; cleaves plasminogen to form plasmin, which degrades fibrin clots
- Prostacyclin: Secreted by endothelial cells; increases platelet levels of cAMP and thus inhibits platelet activation/aggregation; also a vasodilator
- Nitric oxide- Secreted by endothelial cells; acts locally to inhibit platelet activation; potent vasodilator
What are some characteristics of Acute MI?
- Discrete focus of ischemic necrosis in the heart
- Development related to duration of ischemia and metabolic rate of ischemic tissue
- 20-30 minutes of ischemia can cause infarct
- Frequently result of acute plaque change with coronary artery thrombosis
- Dissolution of thrombus frequent within 12-24 hrs
- Infarcts involve LV more commonly and extensively than RV
What is a transmural infarct?
Spans the entire thckness of myocardium; due to prolonged, total occlusion of an epicardial coronary artery (LAD, LCx, RCA or one of the major branches)
What is a subendocardial infarct?
Involves only the innermost layers of the myocardium (most susceptible to ischemia due to poor collateral flow, adjacent to high pressure ventricle, furthest from epicardial coronaries)
The amount of tissue that succumbs to infarction depends on?
- Mass of myocardium perfused by coronary artery
- Magnitude and duration of ischemia
- Oxygen demand of affected area
- Adequacy of collateral coronary flow (collateral flow is supplied by other coronaries)
- Degree of reperfusion and inflammatory response
The LAD supplies which portions of the heart?
- Anterior LV
- Anterior 2/3 septum
- Apical LV
The LCx supplies which portions of the heart?
- Lateral LV
- Posterolateral LV
The RCA supplies which portions of the heart?
- Posterior LV
- Posterior 1/3 septum
- Posterior papillary muscle
- Inferior or diaphragmatic
What are some of the early changes that occur during an MI?
- Rapid shift from aerobic to anaerobic metabolism (lactic acid accumulates)
- Reduction in ATP
- Rising Na+ leading to cellular edema
- Abnormal electrolyte/ion shifts increasing arrhythmia risk (Vtach, vfib)
Irreversible cell injury ensures in 20 min
What are the macroscopic features that occur less than 4 hours after infarction?
No abnormalities
What are the macroscopic features that occur at 4-12 hours after infarction?
Occasional dark mottling
What are the macroscopic features that occur at 12-24hours after infarction?
Dark mottling
What are the macroscopic features that occur at 1-3 days after infarction?
Mottling with developing yellow-tan necrotic center
What are the macroscopic features that occur at 3-14 days after infarction?
Maximally yellow-tan and soft, depressed red-tan borders
What are the macroscopic features that occur at 2-8 weeks after infarction?
Gray-white scar, progressive from border to core of infarct
What are the macroscopic features that occur at greater than 2 months after infarction?
Mature scar
What are the MICROroscopic features that occur less than 4 hours after infarction?
None, variable wavy fibers at border
What are the MICROroscopic features that occur at 4-12 hours after infarction?
Early coagulative necrosis, edema, hemorrhage, wavy fibers
What are the MICROroscopic features that occur at 12-24 hours after infarction?
Coagulative necrosis, nuclear pyknosis, hypereosinophilia, contraction band necrosis, early PMNs
What are the MICROroscopic features that occur at 1-3 days after infarction?
Extensive coagulative necrosis with loss of nuclei and striations, interstitial PMNs
What are the MICROroscopic features that occur at 3-14 days after infarction?
Early disintegration of dead myocytes, dying PMNs, macrophages and granulation tissue at border
What are the MICROroscopic features that occur at 2-8 weeks after infarction?
Gradual loss of cellularity, increasing collagen
What are the MICROroscopic features that occur greater than 2 months after infarction?
Dense collagenous scar
What are some of the impaired systolic changes that occur with MI?
Hypokinesis: Local region with reduced contraction
Akinesis: Local region with no contraction
Dyskinesis: Local region that bulges outward with contraction
What are some of the impaired relaxation/diastolic changes that occur with MI?
Reduced compliance and elevated ventricular filling pressures