Neurotransmitters Flashcards
ACh receptors
Ionotrophic: nicotinic
Metabotrophic: muscarinic
ACh function
Learning Memory Attention Neuromuscular function Alzheimer's
ACh group
Biogenic amine
Serotonin production site
Raphe nuclei in medulla and pons
Serotonin receptors
At least 7 different receptors
Most inhibitory and metabotrophic
Serotonin function
Regulation of mood, control of eating, onset of sleep, control of pain
Ecstasy, shrooms, LSD, SSRIs
Serotonin group
Monoamines
Dopamine production site
VTA, substantia nigra
DA receptors
Metabotrophic
DA function
Reward mechanisms
Attention
Schizophrenia (too much)
Parkinson’s (too little)
DA group
Catecholamines
Norepinephrine (NA) production sites
Locus coeruleus
NA receptor
Inhibitory in CNS (alert, wakefulness)
Excitatory in PNS (target organs of sympathetic NS)
Epinephrine: metabotrophic
NA functions
General arousal
Orienting
Depression
Cocaine, amphetamines
NA group
Catecholamines
GABA receptors
Ionotrophic
GABA function
Local, almost always inhibitory
GABA group
Amino acid
Glutamate receptor
Ionotrophic (3)
1 metabotrophic
Glutamate function
Learning and memory
Almost always excitatory
Glutamate group
Amino acid
Anandamide receptor
Cannabinoid receptors: interfere with 5-HT receptor
Anandamide functions
THC, chocolate
Mood, thinking, sensory perception, coordination, memory
Anandamide group
Neuromodulator
Neurotransmitter
Brain chemicals that communicate info throughout brain and body
Relay signals between neurons
Ionotrophic receptor
Transmitter binding to receptors causes ion channel to open
Fast and short term
Metabotrophic receptor
G-protein mediated
Slow, long-lasting
Uses energy, requires metabolism
Identification of neurotransmitter:
- Chemical and enzyme exist in presynaptic terminal
- Chemical released by action potential
- Chemical applied to synapse artificially induces PSPs
- Blocking release presynaptically induces postsynaptic changes
Agonist
Drug works with neurotransmitter
Antagonist
Drug works against neurotransmitter
Acetylcholine: production site
Nucleus Basalis of Meynert
Septal Nuclei