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Block 3 Pharm > Neuropsychopharmacology Part 1: Antidepressants and Antipsychotics > Flashcards

Neuropsychopharmacology Part 1: Antidepressants and Antipsychotics Flashcards

1
Q

fluoxetine: what is it, side effect

A
  • SSRI antidepressant

- has effects on drug metabolism

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2
Q

sertraline: what is it, advantage over fluoxetine

A
  • SSRI antidepressant

- less effects on drug metabolism than fluoxetine

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3
Q

duloxetine: what is it, use other than major use

A
  • SNRI antidepressant (blocks both serotonin and norepinephrine uptake)
  • neuropathic pain
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4
Q

bupropion: what is it, mechanism, uses other than major use

A
  • atypical antidepressant
  • blocks norepinephrine and dopamine uptake
  • nicotine withdrawal, seasonal affective disorder
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5
Q

mirtazapine: what is it, mechanism

A
  • atypical antidepressant

- blocks presynaptic alpha2 receptors and heteroreceptors in the brain

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6
Q

SSRI antidepressants (2)

A

fluoxetine, setraline

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7
Q

tricyclic antidepressants (2)

A

amitriptyline, clomipramine

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8
Q

symptoms of SSRI discontinuation syndrome; which SSRIs is this more common for?

A
  • dizziness, light-headedness, vertigo, anxiety, fatigue, headache, tremor, visual disturbances
  • sertraline
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9
Q

SSRI with which SSRI discontinuation syndrome is least likely to occur

A

fluoxetine

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10
Q

amitriptyline: what is it, use other than major use

A
  • tricyclic antidepressant

- chronic neuropathic pain

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11
Q

clomipramine: what is it, use

A
  • tricyclic antidepressant

- OCD

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12
Q

phenelzine: what is it, mechanism

A
  • irreversible MAO inhibitor antidepressant

- blocks oxidative deamination of naturally occurring biogenic amines (norepinephrine, dopamine, serotonin)

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13
Q

irreversible MAO inhibitor antidepressant

A

phenelzine

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14
Q

in what dopamine pathway in the brain do positive symptoms of schizophrenia occur?

A

mesolimbic tract

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15
Q

in what dopamine pathway in the brain do negative symptoms of schizophrenia occur?

A

mesocortical tract

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16
Q

typical antipsychotics (4)

A

chlorpromazine, thioridazine, fluphenazine, haloperidol

17
Q

typical antipsychotics: mechanism

A

dopamine D2 antagonists

18
Q

side effects of typical antipsychotics, both short term (5) and long-term (1)

A

short-term: sedation, extrapyramidal symptoms, orthostatic hypotension, weight gain, neuroleptic malignant syndrome
long-term: tardive dyskinesia

19
Q

atypical antipsychotics: mechanism

A

dopamine and serotonin receptor antagonists

20
Q

why atypical antipsychotics are better than typical antipsychotics

A

less extrapyramidal symptoms

21
Q

haloperidol: what it is, mechanism, use

A
  • typical antipsychotic
  • dopamine DA2 antagonist
  • improves positive symptoms of schizophrenia
22
Q

clozapine: what it is, mechanism, use, side effects

A
  • atypical antipsychotic
  • dopamine and serotonin receptor antagonist
  • affects both positive AND negative symptoms of schizophrenia
  • side effects: serious agranulocytosis or blood dyscrasias, less extrapyramidal effects
23
Q

olanzapine: what it is, mechanism

A
  • atypical antipsychotic

- dopamine and serotonin receptor antagonist

24
Q

risperidone: what it is, mechanism

A
  • atypical antipsychotic

- dopamine and serotonin receptor antagonist

25
Q

quetiapine: what it is, mechanism

A
  • atypical antipsychotic

- dopamine and serotonin receptor antagonist

26
Q

aripiprazole: what it is, mechanism, use

A
  • atypical antipsychotic
  • D2 partial agonist, serotonin receptor antagonist
  • adjunct in treatment of depression
27
Q

atypical antipsychotics (5)

A

CORQuA: clozapine, olanzapine, risperidone, quetiapine, aripiprazole

28
Q

drugs used to treat OCD

A

SSRIs and clomipramine

29
Q

SNRI antidepressant: name and mechanism

A

duloxetine; blocks both serotonin and norepinephrine uptake

30
Q

antidepressant also used for neuropathic pain

A

duloxetine

31
Q

atypical antidepressants (2)

A

mirtazapine, bupropion

32
Q

chlorpromazine: what it is, mechanism, use

A
  • typical antipsychotic
  • dopamine D2 antagonist
  • treat schizophrenia
33
Q

thioridazine: what it is, mechanism, use

A
  • typical antipsychotic
  • dopamine D2 antagonist
  • treat schizophrenia
34
Q

fluphenazine: what it is, mechanism, use

A
  • typical antipsychotic
  • dopamine D2 antagonist
  • treat schizophrenia

Block 3 Pharm (17 decks)

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