Neuropsychology Flashcards
Nervous system composed of what?
Central Nervous System and Peripheral Nervous System
What makes up the CNS?
Brain and Spinal Cord
Brain composed of what 3 parts?
- primitive core - sleeping & breathing
- limbic system - basic drives (hunger/thirst) and emotions
(rage/fear/pleasure) - cerebral cortex or cerebrum - higher functions
paraplegia
lower limbs paralyzed
quadriplegia
four limbs paralyzed
hemiplegia
paralysis in an arm and leg on one side of body
paresis
slight or partial paralysis
paresthesia
abnormal sensations such as numbness, tingling or burning
hyperesthesia
abnormal sensitivity to sensation
Peripheral Nervous System
Somatic and Autonomic NS
Somatic Nervous System
controls skeletal muscles
voluntary movement
info from senses
Autonomic Nervous System
“auto” or involuntary activity i.e. BP, heartbeat.
Autonomic arousal correlated with changes in emotionality
Measured by EKG and GS (galvanic skin response)
Autonomic Nervous System divided into what?
Sympathectic - “fight or flight”
Parasympathetic - relaxation, conservation
Action potentials of any given neuron are governed by what?
All-or-None-Law
-action potential is not related to intensity of stimulation,
only minimum has to be reached to generate AP
-intensity can generate more APs to stimulate more neurons
Multiple Sclerosis caused by what?
Loss of myelin - that which increases the speed of
conduction.
Produces muscular weakness, poor coordination, and tremors
Acetylcholine’s effect on muscles
- found in junction bt nerve & muscle fibers
- causes muscles to contract
- defects cause probs w/voluntary mvmt
Neurons that secrete Acetylcholine are called what?
cholinergic neurons
Acetylcholine’s effect on brain
- learning and memory (new memories)
- implicated in Alzheimers (loss of ACh)
- mediates sexual behavior and REM sleep
Name the catecholamines
Norepinephrine, epinephrine and dopamine
Parkinson’s Disease
- too little dopamine
* denigration of substantia nigra neurons in midbrain
Schizophrenia
too much dopamine,
also too much norepinephrine
depression
too little norepinephrine
too little serotonin
GABA
*major inhibitory - depresses activity in NS
*too little = anxiety
*too little in motor areas of brain = Huntington’s Chorea
(invol, jerky mvmts)
Glutamate
major excitatory in CNS
- in hippocampus - memory
- too much may be responsible for brain damage from stroke
Functions of the Medulla Oblonata
- basic functions
- breathing, HR, BP, digestion
- damage is fatal
Functions of the Pons
*arousal states
*raphe nuclei (uses serotonin) - trigger and maintain slow
wave sleep
Functions of the Cerebellum
*balance, coordination, posture
ataxia
*slurred speech, severe tremors, loss balance
(T=tongue/tremors)
*damage to cerebellum produces this
Substantia Nigra
- movement
- part of extrapyramidal motor system
- Parkinson’s disease
Reticular Formation
- sleep and arousal
- pain and touch
- controls reflexes
Reticular Activitating System (RAS)
- crucial for waking state, arousal and attention
* implicated in ADHD
Hypothalamus
- maintains body homeostasis (i.e. metabolism, temp, fluids)
- motivation beh (i.e. drinking, eating, sex, aggression)
- strong feelings into physical responses
- contains suprachiasmatic nucleus (SCN)
What is the suprachiasmatic nucleus (SCN)?
*controls circadian rhythms
Thalamus
- “central relay station”
* relays sensory info to cortex except olfaction
Basal Ganglia
- voluntary movement
* includes caudate nucleus, globus pallidus, and putamen
Extrapyramidal motor system
basal ganglia, substantia nigra, cerebellum
Limbic system
emotional component of behavior
*includes amygdala, septum and hippocampus
Amygdala
- emotional significance to info
- mediates aggressive behavior
- damage produces lack of emotional response
Kluver-Bucy Syndrome
- lesions in amygdala
* reduced fear and aggression, docile, hypersexual
Septum
- part of limbic system
- inhibits emotionality
- damage produces hyper-emotionality and vicious behavior
Hyppocampus
*part of limbic system
*memory consolidation - from short to long term
*damage produces severe, permanent anterograde amnesia
(no new memories)
Damage to hippocampus, amygdala, and medial temporal
lobes produces what?
*severe, permanent anterograde amnesia (no new memories -
think memento)
*retain in short term but can’t recall later
Frontal Lobe
- primary motor cortex
- expressive lang
- higher-order cognitive processes
- orientation to person, place, time
apraxia
*inability to execute purposeful movements, despite normal
strength and coordination (AX)
*damage to frontal/parietal lobes
Broca’s aphasia
*frontal lobe, left hemisphere, speech production, expressive
lang
*speak w/great difficulty (“Broken” english)
*aware of deficits
Prefrontal cortex
- executive functions
- lesions disrupt cognition/planning
- show decreased initiative, lack self-awareness, concrete
“Frontal Lobe Personality”
depressive syndrome (apathy) or psychopathic syndrome (disinhibition - cussing, hypersexual, inappropriate social beh)
Temporal Lobe
- receptive language (primary auditory cortex)
* memory and emotion
Wernicke’s aphasia
temporal lobe, left hemisphere, lang comprehension, receptive lang *receptive or fluent aphasia *nonsense/jibberish speech *dysnomia *unaware of deficits
dysnomia
can’t name familiar objects
Temporal Lobe epilepsy
personality syndrome: intense emotions, religiosity, social
clinging, changes in sexual behavior
Parietal Lobe
- primary somatosensory cortex
* touch-pressure, kinesthesia, pain and temp
Lesions in parietal lobe produce what?
- insensitivity to touch on opp side of body
- contralateral disruption of movement
- tactile agnosia
- impaired spatial orientation and facial recognition
- apraxia
- contralateral neglect
- inability to recognize body parts
- agraphia
Gertsmann’s syndrome
- patterns of deficits caused by lesions to parietal lobe
* agrahia, acalculia, right-left confusion and finger agnosia
Occipital Lobe
*visual cortex
*destruction in either hemisphere results in contralateral
blindness
*less extensive damage causes various
left hemisphere (dominant) controls what functions?
- verbal functions: written/spoken lang
- rational/logical activities
- damage results in clinical depression or intense anxiety
right hemisphere (non-dominant) controls what functions?
*visual-spatial activities
*artistic/musical abilities
*damage results in apathy and indifference, w/exaggerated
but short lived emotional responses
Corpus Callosum
bundle of fibers that enables communication between two
hemispheres
conduction aphasia
*caused by damage to arcuate fasciculus, fibers connecting
Broca’s and Wernicke’s area
*person’s speech makes sense but person cannot repeat what
they just heard