Neuropathology 1 Flashcards
what is the origin of most secondary brain tumours
breast melanoma lung kidney gut lymphoma
what is the most common intracranial primary neoplasm
meningioma
what is the most common primary neoplasm on the malignant spectrum
glioma
what is the most common intracranial peripheral nerve tumour
acoustic schwannoma (neuroma)
what are the features of meningiomas
sporadic post irradiation part of NF2 found where there is arachnoid mater well demarcated slow growing not invasive fits, drowsiness and headaches surgical removal
what does PNET stand for
Primitive neuroectodermal tumours
e.g. medulloblastoma
name some gliomas
oligodendroglioma astrocytoma ependymoma choroid plexus tumours medulloblastoma and primitive neuroectodermal tumours
why is grading important
informs prognosis and treatment
name some peripheral nerve tumours
neuroblastoma, ganglioneuroma
schwannoma
neurofibroma
acoustic neuroma
what is the inheritance of neurofibromatosis 1
autosomal dominant
what are cafe au lait spots associated with
neurofibromatosis
what is MISME, part of NF2
multiple inherited schwannomas, meningiomas and ependymomas
what are the commonest gliomas
astrocytomas
they are on a spectrum of malignancy
what are the features of NF1
most common type
cafe au lait
soft tumours under the skin
learning difficulties
associated with malignant peripheral nerve sheath tumours
50% of cases are sporadic
what are the features of nf2
tumours on nerves responsible for hearing and balance
hearing loss, tinnitus, balance problems
tumours on the brain or spinal cord, arms and legs
50% sporadic
MISME
acoustic schwannoma
