Neuromuscular Junction Workshop Flashcards

1
Q

Cocentration reponse curve

A

with an increase in the concentration of carbachol there is an increase in physiological range

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2
Q

the relationship between concentration and response in a linear plot

A

the relationship between concentration and response is hyperbolic

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3
Q

What is EC50

A

EC50 is the concentration of agonist that elicits a half maximal reponse

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4
Q

Why is linear plot is not used

A

the reason linear plot is not used as it is hard to read the EC50 accurately

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5
Q

semi logarithmic plot

A

The semi logarithmic plot relationship between concentration and response is sigmodial

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6
Q

What does the presence of an antagonist cause to the graph

A

In the presence of an antagonist, the agonist concentration-response curve is ‘shifted to the right’ without a change in maximal response or change in slope (i.e., the ‘shape’ of the concentration response curve remains unchanged)

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7
Q

what does the antagonist action described as

A

the antagonist action of atropine is surmountable over a range of carbachol (agonist) concentration

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8
Q

what does the competitive antagonsit cause

A

Non-competitive antagonists depress the slope and maximum of the concentration response curve, but do not cause a rightward shift

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9
Q

antonist progressive cocentration

A

antagonistProgressive rightward shift of agonist concentration response curve on concentration axis but no depression of slope

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10
Q

Non competitive inhibition

A

Progressive depression of maximum response and slope, but no shift of agonist concentration response curve on the concentration axis

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11
Q

what is IC50

A

IC50 is the concentration of an antagonist where the agonist evoked a response is reduced by 50%

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