Neuromuscular Junction Flashcards
What is the neuromuscular junction?
skeletal muscles innervated by motor neurones
Where is botulism found?
soil and insects
What is the mode of action of botulism?
cleaves pre-synative proteins involving protein formation
What are the clinical features of a botulism infection?
rapid onset of weakness WITH NO SENSORY LOSS
What does Lambart-Eaton Syndrome have a strong association with?
small cell carcinoma
What disease causes symmetrical proximal weakness?
polymyositis
What diseases causes symmetrical proximal weakness with a heliotrope rash?
Dermamyositis
What causes myotonic dystrophy?
Trinucleatide disorder
What is the triad for Rhabdomyolysis?
myalgia
muscle weakness
myoglobinuria
What is Rhabdomyolysis?
damage to skeletal muscle causing leakage of increased quantities of toxic intracellular contents into plasma
What is myotonia?
failure of muscle relaxation after use
What channels are affected in myotonia?
Cl-
What are fasciculations?
visible fine twitch in healthy muscle due to stress or caffeine
