Neuromuscular Drugs and muscle relaxants

Question 1

are those drugs that induce temporary paralysis of skeletal muscles

Answer 1

muscle relaxants

Question 2

Central Acting Muscle Relaxants

Answer 2

1. Guaifenesin
2. Methocarbamol
3. Mephrobamate
4. Mephenesin

Question 3

formerly known as glyceryl gulacolate which is used as an adjunct to anesthesia to produce muscle relaxation and restraint for short procedures

Answer 3

guaifenesin

Question 4

central acting muscle relaxant that is used as an adjunct to rest and physical therapy in the treatment of musculoskeletal injury

Answer 4

methocarbamol

Question 5

Sites of Action of Drugs causing Muscle Relaxation

Answer 5

1. CNS
2. Motor nerve fiber
3. Motor nerve terminal
4. Acetylcholine receptors in motor end plate
5. Skeletal muscle fiber

Question 6

local anesthetic such as __________ can cause muscle relaxation when applied around muscle fibers. however, they are not used for the muscle relaxant effect

Answer 6

lidocaine

Question 7

can relax skeletal muscles but they are not used routinely for the sole purpose of muscle relaxation

Answer 7

general anesthetics (CNS drugs)

Question 8

there are no clinically useful muscle relaxants in this group

Answer 8

motor nerve terminal

Question 9

antibiotics prevent the release of Ach from nerve endings, causing muscle relaxation

Answer 9

botulinus toxin and aminoglycosides

Question 10

Muscle acting on this site are most clinically useful for muscle relaxants

Answer 10

acetylcholine receptors in motor end plate

Question 11

Dantolene decreases sarcoplasmic free calcium concentration by promoting its uptake into the sarcoplasmic reticulum. useful in malignant hyperthermia

Answer 11

skeletal muscle fiber

Question 12

compete with ach for cholinergic receptors in the end plate

Answer 12

nondepolarizing neuromuscular blocking drugs

Question 13

non-competitive blocker of cholinergic receptors in the end plate.

Answer 13

depolarizing neuromuscular blocking drugs