Neuromuscular Blocking Drugs

Question 1

Blocking Nm causes….

Answer 1

muscle relaxation

Question 2

Nondepolarizing Neuromuscular Blocker Examples

Answer 2

cura
curi
curo

Question 3

Nondepolarizing Neuromuscular Blockers

Answer 3

compete with Ach for receptors- competitive antagonist

causes paralysis

Question 4

Cholinesterase Inhibitors

Answer 4

reverse effects of Nm blockers

Question 5

Nm Blockers do not work on….

Answer 5

heart
smooth muscle
CNS

Question 6

Atracurium

Answer 6

breaks down into laudanosine that can cause seizures

Question 7

Cisatracurium

Answer 7

forms less laudanosine

most common muscle relaxant

Question 8

Neostigmine

Answer 8

Ach-esterase inhibitor; allows Ach to continue to Nm receptor and cause stimulation

Question 9

Sugammadex

Answer 9

binds with rocuronium and vecuronium, eliminating their effects

Question 10

Depolarizing Nm Blocker

Answer 10

initially acts as Ach but does not allow another depolarization- causes relaxation

Question 11

Example of Depolarizing Nm Blocker

Answer 11

Succinylcholine

Question 12

Pseudocholinesterase

Answer 12

breaks down Succinylcholine

Question 13

Side Effects of Sch

Answer 13

hyperkalemia

Question 14

Sch should never be used in patients with….

Answer 14

malignant hyperthermia

Question 15

Phase 1 of Depolarizing Nm Blockers

Answer 15

depolarization, fasciculation, prolonged depolarization, flaccid paralysis

Question 16

Phase 2 of Depolarizing Nm Blockers

Answer 16

desensitization

Question 17

AchE Inhibitors and Depolarizing Phases

Answer 17

increase phase 1- inhibitors dont work

reverse phase 2- inhibitors work

Question 18

Spasmolytics

Centrally Acting Skeletal Muscle Relaxants

Answer 18

act in CNS instead of Nm receptor

reduce muscle tone in injury or CNS dysfunction

Question 19

Spasmolytics in Spinal Cord Examples

Answer 19

Diazepam (Valium), Baclofen, Tizanidine

Question 20

Spasmolytics in Spinal Cord

Answer 20

reduces depolarization- decreased action potentials
GABA function increases
decreases muscle spasms

Question 21

Side Effects of Spinal Cord Spasmolytics

Answer 21

drowsiness, confusion, fatigue

Question 22

Spasmolytics in Skeletal Muscle

Answer 22

decreases Ca release, muscle relaxes

Question 23

Uses for Skeletal Muscle Spasmolytics

Answer 23

relax muscle

malignant hyperthermia

Question 24

Examples of Skeletal Muscle Spasmolytics

Answer 24

Dantrolene

Question 25

Botox

Answer 25

prevents release of Ach | causes paralysis locally

Question 26

Used for chronic spasm

Answer 26

botox, dantrolene, diazepam, baclofen