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Pharmacology > Antivirals > Flashcards

Antivirals Flashcards

1
Q

Examples of Anti-HIVs

A

“avir”

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2
Q

Examples of Antiherpes

A

“ovir”

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3
Q

Examples of Antiinfluenza

A

“ivir”

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4
Q

Examples of Antihepatitis

A

“evir”
“uvir”
“ovir”

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5
Q

MoA of Nucleoside Reverse Transcriptase Inhibitors

NRTIs

A

needs 3 phosphates to be active, gets from host

terminates DNA elongation and competes w/ dinucleotides for reverse transcriptase

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6
Q

Examples of NRTIs

A

zidovudine, lamivudine, emtricitabine

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7
Q

Adverse Effects of NRTIs

A

bone marrow suppression

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8
Q

Least Toxic NRTIs

A

lamivudine and emtricitabine

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9
Q

MoA of Nucleotide Reverse Transcriptase Inhibitors

NtRTI

A

needs 2 phosphates to be active

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10
Q

Use of NRTIs

A

HIV- inhibits reverse transcriptase

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11
Q

Examples of NtRTIs

A

Tenofovir

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12
Q

Use of NtRTIs

A

HIV- inhibits reverse transcriptase

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13
Q

MoA of Non-nucleoside Reverse Transcriptase Inhibitors

NNRTIs

A

no phosphates needed

bind to reverse transcriptase below catalytic site

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14
Q

Examples of NNRTIs

A

efavirenz

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15
Q

Protease Inhibitors

A

inhibits HIV1 protease that makes more virions

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16
Q

Examples of Protease Inhibitors

A

ritonavir

17
Q

Adverse Effects of Protease Inhibitors

A

central adiposity

insulin resistance- hyperglycemia

18
Q

MoA of Enfuviritide

A

blocks gp41 protein on T cell survace to prevent HIV entry

19
Q

MoA of Maraviroc

A

blocks CCR5 protein on macrophage to prevent HIV entry

20
Q

MoA of Raltegravir

A

inhibits HIV integrase- integrates genetic material into human chromosomes

21
Q

PrEP

A

given to patients at high risk for exposure to HIV

22
Q

Shingles

A

later in life after chickenpox

presents with painful dermatomal rash

23
Q

MoA of Acyclovir

A

needs 3 phosphates to activate

1 from herpes, 2 from host

24
Q

Cidofovir

A

only activated by host phosphates

used in TK- strains of herpes (dont give up P)

25
Q

Ganciclovir Use

A

used for CMV retinitis

26
Q

Adverse Effects of Ganciclovir

A

bone marrow suppression

27
Q

Foscarnet

A

inhibits pyrophosphate binding site on herpes DNA polymerase

28
Q

Oseltamivir

A

blocks neuraminidase, inhibiting budding and release of viral flu from cell

Pharmacology (12 decks)

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