Neurology Flashcards
Difference between seizure and epileptic seizure?
Epileptic seizure is an excessive and hypersynchronous self-limiting activity of neurons in the brain
Taking a history of a seizure, what do you ask about before the event?
Time of day What were you doing at the time? Any triggers Any warnings like behavioural changes Was it sudden or gradual Well before the episode? were they feeling funny? Chances of being poisoned?
When taking a history of a seizure, what do you ask about the event itself?
Movement - eyes, head, which limbs, symmetrical, flex or extend, hypertonic or hypotonic, jerking (clonic), sudden jerks Pallor Cyanosis Eyes open or closed Awareness Tongue biting Incontinence
When taking a history of a seizure, what do you ask about after the event?
When did it stop? Gradual/sudden? How long till returned to normal? Post-ictal confusion sleepy?
What is it always important to have before epilepsy diagnosis can be made?
Eye witness
What is the differential diagnosis to epilepsy?
Non-epileptic paroxysmal events
List 10 types of non-epileptic paroxysmal events?
Vasovagal syncope Cardiogenic syncope Breath holding Reflex anoxic spells Blank spells/day dreaming Sandifer Syndrome fabricated illness sleep phenomena self gratification benign neonatal sleep myoclonus benign paroxysmal vertigo and torticollis Tics Pseudoseizures
Cardiogenic syncope often is found to have what? Triggers?
QT prolongation
FH of sudden death
Triggered by exercise and sleep
What is Sandifer syndrome?
Present in complex neurodisability triggered by feeding and leaves patients with GORD and pain
2 examples of idiopathic generalised seizures in children?
CAE (childhood absence seizures)
JME (juvenille myoclonic epilepsy)
A type of idiopathic focal epilepsy in children?
BREC (benign rolandic epilepsy of chidhood)
2 epileptic encephalopathies that can develop in children?
Wests syndrome
Dravet Syndrome
Describe benign neonatal sleep myoclonus?
Brief jerks whilst asleep that don’t bother neonate
Grows out of it in 6-8 months
Infantile spasms - when do they present? symptoms? cry? assocaited to what syndrome? 2 underlying causes?
Presents 2 months-1year
Symptoms = myoclonic jerks of head, limbs or trunk, clusters on waking
Cry between spasms whereas colic cry during
Assocaited to Wests syndrome - infantile spasms, developmental delay and Hips arrythmia on EEG
underlying causes can be Down’s Syndrome or Tuberous Sclerosis
How do you treat infantile spasms?
Steroids
How do you treat infantile spasms if the underlying cause is tuberous sclerosis?
Vigabatrin
2 things that make a febrile illness become complex?
More than 2 seizures in a 24 hours period
Seizure for longer than 15 minutes
Age group usually effected by febrile seizures?
6 months to 5 years
When do you treat febrile illness?
If they enter status epilepticus which is prolonged seizure for 15-20 minutes then treat with buccal Midazolam
Describe the typical picture of breath holding spells? resolves by what age?
child crying, louder then collapses and seizes, return to normal
Resolve by age 2/2.5
What causes reflex anoxic seizures? typical picture?
Hypoxic drive for seizure activity
Suddenly go limp then clonic jerks
pallor
Usual age onset of CAE? features during and after?
4-8 years old eye or mouth flickering Little finger movements Peri-orbital and periocular flickering Last 20 seconds No post-ictal confusion
How do you diagnose CAE alongside clinical appearance?
2 second spike and wave on EEG
Key feature of BREC? age?
facial or periorbital onset of focal epilepsy
3-13 years