Neurology Flashcards

1
Q

Difference between seizure and epileptic seizure?

A

Epileptic seizure is an excessive and hypersynchronous self-limiting activity of neurons in the brain

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2
Q

Taking a history of a seizure, what do you ask about before the event?

A
Time of day
What were you doing at the time?
Any triggers
Any warnings like behavioural changes
Was it sudden or gradual
Well before the episode? were they feeling funny?
Chances of being poisoned?
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3
Q

When taking a history of a seizure, what do you ask about the event itself?

A
Movement - eyes, head, which limbs, symmetrical, flex or extend, hypertonic or hypotonic, jerking (clonic), sudden jerks
Pallor
Cyanosis
Eyes open or closed
Awareness
Tongue biting
Incontinence
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4
Q

When taking a history of a seizure, what do you ask about after the event?

A
When did it stop?
Gradual/sudden?
How long till returned to normal?
Post-ictal confusion
sleepy?
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5
Q

What is it always important to have before epilepsy diagnosis can be made?

A

Eye witness

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6
Q

What is the differential diagnosis to epilepsy?

A

Non-epileptic paroxysmal events

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7
Q

List 10 types of non-epileptic paroxysmal events?

A
Vasovagal syncope
Cardiogenic syncope
Breath holding
Reflex anoxic spells
Blank spells/day dreaming
Sandifer Syndrome
fabricated illness
sleep phenomena
self gratification
benign neonatal sleep myoclonus
benign paroxysmal vertigo and torticollis
Tics
Pseudoseizures
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8
Q

Cardiogenic syncope often is found to have what? Triggers?

A

QT prolongation
FH of sudden death
Triggered by exercise and sleep

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9
Q

What is Sandifer syndrome?

A

Present in complex neurodisability triggered by feeding and leaves patients with GORD and pain

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10
Q

2 examples of idiopathic generalised seizures in children?

A

CAE (childhood absence seizures)

JME (juvenille myoclonic epilepsy)

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11
Q

A type of idiopathic focal epilepsy in children?

A

BREC (benign rolandic epilepsy of chidhood)

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12
Q

2 epileptic encephalopathies that can develop in children?

A

Wests syndrome

Dravet Syndrome

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13
Q

Describe benign neonatal sleep myoclonus?

A

Brief jerks whilst asleep that don’t bother neonate

Grows out of it in 6-8 months

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14
Q

Infantile spasms - when do they present? symptoms? cry? assocaited to what syndrome? 2 underlying causes?

A

Presents 2 months-1year
Symptoms = myoclonic jerks of head, limbs or trunk, clusters on waking
Cry between spasms whereas colic cry during
Assocaited to Wests syndrome - infantile spasms, developmental delay and Hips arrythmia on EEG
underlying causes can be Down’s Syndrome or Tuberous Sclerosis

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15
Q

How do you treat infantile spasms?

A

Steroids

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16
Q

How do you treat infantile spasms if the underlying cause is tuberous sclerosis?

A

Vigabatrin

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17
Q

2 things that make a febrile illness become complex?

A

More than 2 seizures in a 24 hours period

Seizure for longer than 15 minutes

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18
Q

Age group usually effected by febrile seizures?

A

6 months to 5 years

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19
Q

When do you treat febrile illness?

A

If they enter status epilepticus which is prolonged seizure for 15-20 minutes then treat with buccal Midazolam

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20
Q

Describe the typical picture of breath holding spells? resolves by what age?

A

child crying, louder then collapses and seizes, return to normal
Resolve by age 2/2.5

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21
Q

What causes reflex anoxic seizures? typical picture?

A

Hypoxic drive for seizure activity
Suddenly go limp then clonic jerks
pallor

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22
Q

Usual age onset of CAE? features during and after?

A
4-8 years old
eye or mouth flickering
Little finger movements
Peri-orbital and periocular flickering
Last 20 seconds
No post-ictal confusion
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23
Q

How do you diagnose CAE alongside clinical appearance?

A

2 second spike and wave on EEG

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24
Q

Key feature of BREC? age?

A

facial or periorbital onset of focal epilepsy

3-13 years

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25
What are the 2 classic prodromal symptoms of BREC do children tend to suffer? Other potential prodromes?
Unilateral numbness and paraesthesia of the lips, gums, cheek Involuntary movements of the jaw Expressive speech arrest
26
4 post-ictal features of BREC?
guttural sounds speech arrest hypersalivation difficulty swallowing
27
EEG characteristic feature of BREC?
bilateral or unilateral centrotemporal spikes
28
Prognosis of BREC?
90% remission by 16 years old
29
Juvenille myoclonic epilepsy? age of onset? EEG findings? treatment options? prognosis in comparison to CAE?
onset at 12 years old Absence seizures, GTC, myoclonic EEG sees 3 per second spike and wave Treatment with sodium valproate and lamotrigine
30
Juvenile myoclonic epilepsy onset age? type of seizure? often confused with what? EEG shows what? Treatment? Prognosis?
12-18 years onset GTC seizures Often confused with daydreaming - clumsy, dropping stuff in morning EEG shows polyspike waves with irregular slow waves Treatment is with sodium valproate and lamotrigine Prognosis is lifelong disorder
31
Conditions that relate to development of cerebral palsy?
Prematurity Hypoxic ischaemic encephalopathy metabolic disease Acquired brain injury
32
Define cerebral palsy
Non-progressive non changing disorder due to malformations in brain development
33
What are common comorbidities suffered from those with cerebral palsy?
``` Difficulties feeding Epilepsy Sensorineural deafness Visual impairment Gut motility issues Retinopathy of prematurity ```
34
GMFCS 1 vs GMFCS 5 in terms of cerebral palsy classification
GMFCS 1 = no walking aids needed | GMFCS 5 = wheelchair and poor head control
35
Which cause of cerebral palsy is most likely to end up as a quadriplegiac?
CP caused by prematurity
36
Cardinal features of cerebral palsy?
dystonia spasticity pain
37
What is dystonia and which type of cerebral palsy cause usually presents with it?
involuntary movements of the limbs | Usually in full term hypoxic events that damage the basal ganglia
38
Dystonia causes that arent caused by damage to the basal ganglia?
``` Dopa responsive dystonia Biotinidase deficiency Methyl malonic aciduria Glutaric aciduria type 1 GLUT 1 deficinecy Inherited DYT1/DYT11 ```
39
How does spasticity form in cerebral palsy and what does it present as?
Damage to motor pathways High tone movement disorder Increased reflexes Clonus
40
3 main forms of pain in cerebral palsy?
dental pain, bone pain and gastric pain
41
What can the pain in cerebral palsy impact the persons life?
``` Seizures become worse dystonic positioning difficult sleeping poor feeding irritable and challenging behaviour ```
42
What kind of MDT team is involved in CP?
``` Paediatrician Physiotherapist OT GP Respite SLT Neurologist SW ```
43
4 main MSK issues suffered by patients with CP?
scoliosis Hip dislocation Muscle contracture Plantar flexed feet and toe walking
44
Main prevention methods of worsening MSK issues in children with CP?
Prevention schemes - walking and moving Medication to decrease tone Postural management - chairs, beds
45
Common sites for Botulinum toxin injections to be administered? Who needs to be involved in management of patients recieving them? Benefit? How long do they last?
Iliopsoas, hamstrings, adductors OT - train antagonist muscle whilst the agonist are paralysed last for 3-4 months with peak at 1 month
46
What is the CDC input in post injection therapy for cerebral palsy patients?
``` 8 weeks once a week treatment sessions, monitoring, review Goal setting Liaison with school Ongoing monitoring 2/3 review sessions in months 3/4 ```
47
What GABA agonist is commonly used to treat cerebral palsy that presents as a high tone disorder such as spasticity?
Intra-thecal baclofen
48
What is the gold standard trio of medication for managing dystonia in cerebral palsy? alternative?
Haloperidol + tetrabenazine + trihexyphenidyl | Deep brain stimulation
49
How is a Baclofen pump placed in situ and who is it administered to?
Placed inside abdomen with leads into spinal cord Spasticity and dystonia indications in older ambulatory children with either severe spasticity in upper and lower extremities or spinal injury
50
In deep brain stimulation what the rods target?
Basal Ganglia
51
Define Neural tube defect?
developmental disorder of the brain, spine or spinal cord occurring in the first trimester of pregnancy
52
3 types of spina bifida?
Spina bifida occulta, meningocele, myelomeningocele
53
How does spina bifida occulta present?
dimples in back, hair tuft, lipoma, adhesions can potentially cause sensory or motor disturbances
54
Meningocele?
Vertebral cleft and meninges in CSF
55
Myelomeningocele?
Vertebral cleft with meninges and nervous tissue
56
Antenatal USS reveals what signs of spina bifida?
Lemon sign Banana sign Ventriculomegaly Posterior vertebral arch defects
57
What screening blood test can be done in early pregnancy to assess for spina bifida? how many weeks gestation?
AFP in maternal blood
58
Preventable causes of spina bifida?
Folic acid deficiency AEDs - sodium valproate, phenytoin, carbemazepine Maternal diabetes
59
Why do AEDs cause spina bifida?
Reduce folate stores
60
If the spina bifida occurs at the S2-S4 level what are the symptoms?
can usually walk with shoe inserts
61
If the spina bifida occurs at the level L5-S1 level what are the symptoms?
Walk with short ankle braces | Crutches
62
If the spina bifida occurs at the L4 level what are the usual symptoms?
Can use braces that go above the knee Wheelchair often preferred for long distances Braces for short distances
63
If the spina bifida occurs at the level L2-L3 what are the usual symptoms?
Can have braces above knee/hip | Usually end up using wheelchair majority of time
64
is the spina bifida occurs at the level T12-L1 what are the usual symptoms?
Younger may walk with braces above hip | Usually end up just using wheelchair
65
Why is surgical intervention often needed with higher lesion spina bifida?
Scoliosis
66
Apart from walking, what other complications does spina bifida often come with?
Sensory issues Neuropathic bowel Neuropathic bladder
67
Management of neuropathic bowel?
laxatives suppositories bowel training rectal washouts
68
2 main types of neuropathic bladder that can develop in spina bifida? complications associated?
sphincter tight shut - reflux, renal damage, CKF | Sphincter loose and open - incontinence, stagnant bladder, UTI
69
80% of myelomeningocele patients will suffer with what? Associated with what? What is needed as treatment?
Hydrocephalus Chiari 2 malformation Ventriculoperitoneal shunt
70
Infant presenting with shunt malformation?
``` Lethargy Poor feeding Vomiting Irritable Seizure LOC ```
71
Child presenting with shunt malformation?
``` Headache Visual loss Dizzy Vomiting Personality changes developmental delay LOC Seizure ```
72
High AFP on 15-20 week screen of mother suggests what 2 possibilities?
Myelomeningocele and anencephaly
73
How does USS determine spina bifida?
Lemon and banana sign - ventriculomegaly and microcephaly
74
In motor defects of spina bifida where are the main referrals made to?
OT Physio Orthopaedics Child development clinic
75
Urinary issues in spina bifida investigated and managed how?
MCUG USS Videourodynamics Self-catheterisation and UTI prophylaxis
76
What is given for bowel problems suffered in spina bifida patients?
Glycerol suppositories
77
In spina bifida, what support group is a good one to suggest?
SHINE charity
78
Symptoms of VP shunt blockage in baby?
``` Lethargy Poor feeding Vomiting Seizure LOC ```
79
Symptoms of VP shunt blockage in child?
``` Developmental delay Headache Visual loss Dizziness Vomiting Seizures LOC Unsteady Irritable ```
80
How do you diagnose shunt malfunction?
CT brain | Shunt series
81
AFO? KAFO? HKAFO?
Ankle foot orthoses Knee ankle foot orthoses Hip knee ankle foot orthoses
82
Child with spina bifida is starting to hate having to self-cathetrise, who do you refer to?
Specialist continence nurse | SHINE
83
If a child with spina bifida presents with incontinence every day what are investigations performed?
MRI spine - tethering Videourodynamics - pressures, compliance CT brain - shunt malformations
84
Symptoms suggestive of cord tethering?
Progressive limb deterioration Change in urinary habits Progressive scoliosis Pain
85
Associated symptoms to ask about in headache history?
``` nausea vomiting aura visual disturbances balance fever personality changes numbness or paraesthesia ```
86
In terms of the pattern and time course to a headache what questions do you want to ask?
Morning? night? | after exercise? argument? eating? trauma? travel?
87
What relieving factors do you want to ask about with headache history?
``` Lying down Dark room Paracetamol Sitting down Eating ```
88
What questions can you ask to assess how much headaches are effecting a childs quality of life?
If they have to leave school? how many times? Sleep effected? Daily activities effected?
89
Medication history of a child with a headache what is it important to ask about?
Anticoags, antoplatelet, contraception Allergies Vaccines up to date OTC - eye drops, nasal decongestants, herbal
90
FH questions to ask about migraines?
``` headaches, migraines kidney problems, high BP eye problems - any one wear glasses? Familial tumours Blood vessel abnormalities - aneurysms, malformations, coagulopathy ```
91
SH questions to ask about migraine?
``` Who lives at home? Any social worker? Pets? School? progress? enjoy? any developmental concerns? Hobbies and activities? ```
92
Things to assess in a neurology exam to assess headaches?
Gait Coordination CNS - power, tone, coordination, reflex, sensation PNS - cranial nerve 1-12 Eye exam - movements, acuity, nystagmus, diplopia, pupils, fundoscopy
93
What symptoms make you worried about a space occupying lesion with a headache?
Headache worse in morning, vomiting, sleep disturb
94
If CT is performed for papilloedema and finds no brain abnormality, what 2 tests can you perform?
Lumbar puncture for pressure reading | MRI brain for more accurate imaging
95
Differential diagnosis of seizures in children?
Epilepsy - idiopathic or secondary to damage Metabolic - dka, hypocalcaemia, hypomagnesaemia, hypo or hypernatraemia Trauma - intracranial haemorrhage, NAI Infection - meningitis, encephalopathy Cardiac - arrhythmia, long QT syndrome Breath holding Toxins Poisoning Causes of a seizure - febrile illness, reflex anoxic attacks, sleep apnoea, pseudoseizures, fabricated illness
96
Difference between simple and complex febrile illness?
Simple - 6 months to 5 years, fever, GTCS, less than 15 minutes, full neuro in an hour, no CNS infection Complex - Focal onset, does not fully recover in an hour, more than 15 minutes, reoccurrence within 24 hours
97
When do you admit a child to hospital for a seizure?
``` Complex seizure First seizure Hasn't been assessed by paediatrician Parental anxiety Fever not present More serious infection suspected Child is on antibiotics ```
98
2 deficiencies that can lead to increased risk of febrile seizures?
Zinc and iron
99
What infection can predispose a child to their first febrile seizure?
Herpes virus 6
100
Dose of paracetamol given to children under 1 years old? 1-3 years old? 4+ years old?
120mg 240mg 360mg
101
rectal and buccal rescue treatments for febrile seizures?
Rectal diazepam | Buccal midazolam
102
What physical examinations need to be performed for a child experiencing seizures? (including one examiantion with light)
``` Facial dysmorphic features cafe au lait spots, woods light HC fundoscopy Bruits BP Neurodevelopmental exam Mental state ```
103
What investigation should never be forgotten in a child presenting with seizure?
Blood glucose
104
Epilepsy support groups?
British epilepsy association and epilepsy action
105
If buccal midazolam isnt working what can be given IV in hospital setting?
IV lorazepam 0.1mg/kg
106
If IV lorazepam isnt working then what is given IV to resolve seizure?
Phenytoin 20mg/kg over 20 minutes