Neurology Flashcards
What is Hoover’s sign as it pertains to Somatisation disorder?
Hoover’s sign is the test used to help differentiate organic v non-organic / functional leg paresis
You place a hand under the affected leg while asking them to lift the unaffected leg against resistance - you will feel counter pressure in the ‘affected’ leg due to involuntary hip extension
When should phenytoin levels be checked?
Phenytoin levels do not need to be checked routinely but should be checked if suspect toxicity or if change of dose.
Need to check TROUGH levels so just before dose is due.
What is the classical presentation for normal pressure hydrocephalus?
Normal pressure hydrocephalus is an important differential to consider in patient’s presenting with confusion / memory loss as it is a REVERSIBLE cause of dementia.
It is caused by reduced resorption of CSF through the arachnoid villi.
Presents with WACKY, WET, WOBBLY
1. Cognitive disturbance / memory loss
2. Urinary incontinence
3. Wide, unstable gait (may present quite similar to parkinsons gait)
Management is ventricloperitoneal shunting
Which medications may cause peripheral neuropathy?
Nitrofurantoin
Metronidazole
Amiodarone
Isoniazid
Vincristine
In what ways does the classical presentation of migraines differ in children versus adults?
In children migraines are more likely to be *Bilateral *Last for shorter periods and have *Gastrointestinal disturbance / abdo pain associated
What DMARDs are available for those with MS?
Natalizumab - can reduce freq and severity of relapses by ~ 68%
Beta interferon (reduces relapses by ~ 30%)
The efficacy of cannabinoids is still debated
IF THE PATIENT HAS BEEN UNABLE TO WALK FOR 6 MONTHS THEN DMARDS ARE UNLIKELY TO BE EFFECTIVE
If there is disease progression despite treatment then normally that treatment should be stopped
Which patients with epilepsy would NOT be suitable to management under primary care and would require secondary care?
Any child / adolescent
Any adult with special needs
Any adult with ongoing seizures or with specific care needs e.g planning a pregnancy/
** Only adults with stable, well-controlled epilepsy should be managed in primary care **
What are the typical signs of lower and upper motor neurone lesions respectively?
UMN - hyperreflexia, spasticity, weakness, upgoing / extensor plantar response
LMN - reduced reflexes, flaccid paralysis, atrophy, fasciculations
What is the typical presentation of amyotrophic lateral sclerosis?
Mixed upper and lower motor neurone signs, involving initially one segment of the neuroaxis (i.e., cranial, cervical, thoracic, or lumbosacral), and then progressively spreading, typically to contiguous areas
What is the most common form of motor neurone disease?
Amyotrophic lateral sclerosis (ALS)
Which medication is shown to prolong survival in ALS and should be offered to all at diagnosis?
Riluzole
What is the first line drug for trigeminal neuralgia?
Carbamazapine
Carbamazepine is the only licensed anticonvulsant medication with proven efficacy to treat trigeminal neuralgia.
Initiate therapy at 100 mg up to twice daily, and titrate in steps of 100–200 mg every 2 weeks, until pain has been relieved.
In the majority of people a dosage of 200 mg three or four times a day is sufficient to prevent paroxysms of pain (maximum dosage 1600 mg daily).
Modified release preparations may be useful, particularly if the person experiences breakthrough pain at night. Once the pain is in remission, the dosage should be gradually reduced to the lowest possible maintenance level, or the drug can be discontinued until a further attack occurs
IF CARBAMAZEPINE DOES NOT WORK THEN REFER TO A SPECIALIST
According to NICE, within what window of time should people who sustain a head injury on anticoagulants (warfarin or NOAC) get a CT Head?
Within 8 hours
What is the typical presentation of diabetic amyotrophy?
PAINFUL mononeuropathy
Often affects the femoral nerve (normally unilateral) leading to wasting of the quadriceps, and LMN signs including loss of knee jerk as well as pain and numbness in the affected dermatome
