neurology Flashcards

1
Q

why is child neurology considered dynamic?

A
  • brain continues to grow and function evolves

- static lesions produce evolving features

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2
Q

give examples of common neurological problems in childhood

A
  • headache
  • fits, faints, funny turns
  • unusual head
  • neuromuscular disorders
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3
Q

what is assessed in a developmental history?

A
  • motor milestones: gross and fine motor skills
  • speech and language
  • vision and hearing
  • play
  • self-help skills
  • cognitive development
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4
Q

what is looked at in a paediatric neurological examination?

A
  • appearance
  • gait
  • head size
  • skin findings
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5
Q

what is the epidemiology of headache disorders?

A
  • 40% of children by age 7

- 75% of children by age 15

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6
Q

what are the 4 classifications of headache?

A
  • isolated acute
  • recurrent acute
  • chronic progressive
  • chronic non-progressive
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7
Q

what do you want to know about the typical episode of chronic headache?

A
  • warning
  • location
  • severity
  • duration
  • frequency
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8
Q

what does a headache examination consist of

A
  • growth parameters, OFC, BP
  • sinuses, teeth, cranial bruit
  • visual acuity, visual fields (craniopharyngioma), fundoscopy
  • focal neurological signs
  • cognitive and emotional status
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9
Q

what features would suggest childhood migraine?

A
  • abdominal pain, nausea, vomiting
  • focal signs: visual disturbance, paraesthesia, weakness
  • pallor
  • photophobia, phonophobia
  • relation to fatigue/stress
  • relieved by sleep/rest/ dark, quiet room
  • family history
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10
Q

what is the typical presentation of migraine?

A
  • hemicranial pain
  • throbbing/pulsatile
  • abdo pain, nausea, vomiting
  • relieved by rest
  • photophobia/phonophobia
  • visual, sensory, motor aura
  • positive family history
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11
Q

what is the typical presentation of tension headache?

A
  • diffuse, symmetrical
  • band-like distribution
  • present most of the time (but there may be symptom free periods)
  • “constant ache”
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12
Q

what type of headache would suggest raised intracranial pressure?

A

aggravated by activities that raise ICP eg. coughing, straining at stool, bending

woken from sleep with headache +/- vomiting

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13
Q

what type of headache would suggest analgesic overuse headache?

A

headache is back before allowed to use another dose

- paracetamol/NSAIDs, compound analgesics eg cocodamol

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14
Q

what are the indications for neuroimaging in headache?

A
  • cerebellar dysfunction
  • raised intracranial pressure
  • new focal neurological deficit eg. new squint
  • seizures, esp focal
  • personality change
  • unexplained deterioration of school work
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15
Q

how is migraine treated in children?

A

acute attack: effective pain relief and triptans

preventative: pizotifen, propranolol, amitryptiline, topiramate, valproate

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16
Q

how are tension type headaches treated in children?

A
  • acute attacks: simple analgesia
  • prevention: amitryptiline
  • discourage analgesics in chronic TTH
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17
Q

what are paroxysmal events

A
  • seizure/fit
  • syncope
  • convulsion
18
Q

what is a seizure/fit

A

sudden attack from whatever cause

19
Q

what is epilepsy?

A

tendency to recurrent, unprovoked (spontaneous) epileptic seizures

20
Q

what is an epileptic seizure

A

abnormal excessive hypersynchronous discharge from a group of (cortical) neurons

paroxysmal change in motor, sensory or cognitive function

depends on seizure’s location, degree of anatomical spread over cortex, duration

21
Q

what non-epileptic seizures and mimics can occur in children?

A
  • acute symptomatic seizures: hypoxia-ischaemia, hypoglycemia, infection, trauma
  • syncope
  • reflex anoxic seizure
  • parasomnias eg. night terrors
  • behavioural stereotypies
  • psychogenic seizures (NEAD: Non-epileptic attack disorder)
22
Q

what is febrile convulsion?

A

a seizure occurring in infancy/childhood (3 months - 5 years)
associated with fever but without evidence of intracranial infection or defined cause for the seizure

23
Q

what are the different seizure types?

A

jerk/shake: clonic, myoclonic, spasms

stiff: tonic seizure
fall: atonic/ tonic/ myoclonic

vacant attack: absence, complex partial seizure

24
Q

what is the mechanism of epileptic fits?

A

chemical stimulation produces an electrical current

summation of a multitude of electrical potentials results in depolarisation of many neurons which can lead to seizures

can be recorded from surface electrodes (electroencephalogram)

25
what are the types of epileptic seizures
partial seizure generalised seizure
26
what are epileptic fits chemically triggered by
- decreased inhibition (gama-amino-butyric acid, GABA) - excessive excitation (glutamate and aspartate) - excessive influx of Na and Ca ions
27
what is a focal seizure?
seizure restricted to one hemisphere or one part of the one hemisphere
28
what is a generalised seizure?
abnormal activity in both hemispheres
29
what are EEGs useful in?
identifying seizure types, syndrome and aetiology
30
What are the disadvantages of using EEG for diagnosis of fits?
Problematic false positives - Paroxysmal activity seen in 30% - Frankly epileptiform activity in 5% of normal children
31
how are seizures/fits diagnosed?
- history - video recording of event - ECG in convulsive seizures - interictal/ ictal EEG - MRI Brain: to determine aetiology - genetics - metabolic tests
32
when should anti-epileptic drugs be considered for use in children?
if diagnosis is clear even if this means delaying treatment
33
what should be considered when choosing anti-epileptics drugs?
- age - gender - type of seizures - epilepsy
34
what are the possible side effects of anti-epileptic drugs?
CNS related - drowsiness - effect on learning - cognition and behavioural effects
35
describe the management of epilepsy
sodium valproate (not in girls)/ levetiracetam carbamazepine (focal) other: steroids, immunoglobulins, ketogenic diet
36
what is microcephaly and macrocephaly
microcephaly: OFC < 2 SD macrocephaly: OFC > 2SD OFC - occipitofrontal circumference
37
what do neuromuscular disorders affect?
disorders of the peripheral nervous system from the anterior horn cells down
38
when should you suspect a neuromuscular disorder?
- baby ‘floppy’ from birth - slips from hands - paucity of limb movements - alert, but less motor activity - delayed motor milestones - able to walk but frequent falls
39
what is Duchenne muscular dystrophy?
delayed gross motor skills symmetrical proximal weakness: waddling gait, calf hypertrophy, gower's sign elevated creatine kinase levels complications: cardiomyopathy, respiratory involvement
40
give examples of neuromuscular conditions
muscle: muscular dystrophies, myopathies (congenital and inflammatory), myotonic syndromes neuromuscular junction: myasthenic syndromes nerves: hereditary or acquired neuropathies anterior horn cells: spinal muscular atrophy