Neurodevelopment Flashcards

1
Q

How many connections in the adult brain? How many neurons?

A
  • 60 trillion connections

- 100 billion neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How much does the brain weigh?

A
  • 3 pounds
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How doe the brain structurally development?

A
  • starts with neural tube within first few weeks of pregnancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is grey and white matter?

A
  • grey: cell bodies of neurons

- white: axons with myelin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the neocortex?

A
  • thin mantle that lies on the surface of the brain

- grey matter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the nuclei?

A
  • deep pockets of grey matter that send information to the neocortex
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When are the majority of neurons formed?

A
  • first half of pregnancy

- must be produced at 200,000 neurons/minute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When does brain development occur?

A
  • from 20 days conceived to early adolescents
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does the amount of neurons in infants compare to adults? What does this mean?

A
  • twice as many neurons as adult
  • twice as many connections
  • means that development must include and overproduction and pruning back of neurons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How do brain regions differ in overproduction and pruning back?

A
  • pattern is the same
  • timing is different
  • so different peak times in different regions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Why do cells die during development?

A
  • only cells that are part of functioning networks have access to Nerve Growth Factor
  • when they don’t make connections, they die off
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

When does sensory/motor function begin?

A
  • prenatally
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the two streams of thought on how the brain develops?

A
  • innate: biologically predetermined
  • emergent: influenced by experience
  • nature AND nurture
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is plasticity?

A
  • new brain structures and functions build upon earlier developing ones
  • the development of each new structure requires the interaction of genetic cues and input from the environment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are genes?

A
  • two strands of DNA coiled together in double helix
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do genes do?

A
  • not one gene for eye colour, artistic talent, etc.
  • many genes contribute to development
  • provide a template for making proteins
17
Q

Which two genes work together to define basic neocortical areas?

A
  • Pax6 and Emx2
18
Q

Where are Emx2 and Pax6 expressed?

A
  • Emx2: high concentration in back and middle

- Pax6: high concentration in front and sides

19
Q

What levels of Emx2 and Pax6 signal cells to take on which functional roles?

A
  • high Emx2 and low Pax6: vision
  • high Pax6 and low Emx2: motor
  • intermediate of both: touch
20
Q

What happens if Emx2 expression is lowered?

A
  • expression of Pax6 moves further backward
  • vision contracts
  • motor and touch expand and shift backward
21
Q

What happens if Pax6 expression is lowered?

A
  • brain areas shifted forward
  • vision expands
  • motor and touch contract
22
Q

How did the rats differ in the different environments?

A
  • animals in enriched environment make more synapses and maintain over life
  • for young rats and adult rats