Neurocognitive disorders

Question 1

What is ideational apraxia?

Answer 1

The inability to put a sequence of skilled acts together in a row, though the individual may be able to perform each component of the sequence without error. Usually involves the left parietal cortex and the executive functions of the prefrontal cortex. Seen in Alzheimer’s disease.

Question 2

What gene is most implicated in early onset Alzheimer’s?

Answer 2

Presenilin 1

Question 3

What is the presentation of normal pressure hydrocephalus?

Answer 3

Usually in patients > 60 yrs old. The classic syndrome consists of urinary incontinence, gait abnormality, and dementia (wet, wobbly, and wacky)

Question 4

What are symptoms of chronic subdural hematomas (usually caused by trauma, ruptured aneurysms, AVMs, or deacceleration injuries)?

Answer 4

Headache, confusion, inattention, apathy, memory loss, drowsiness, and coma

Question 5

What medication is useful for treating psychotic symptoms related to delirium?

Answer 5

Haloperidol

Question 6

What is the first line medication for treating symptoms of Alzheimer dementia?

Answer 6

Donepezil - least amount of side effects of the cholinesterase inhibitors

Question 7

What are the neurologic and psychiatric manifestations of Wilson’s disease?

Answer 7

Parkinsonism, gait disturbance, dysarthria, depression, personality changes, and psychosis