Neurobiology Flashcards
Ion channels are dependent of what exactly and are made of what structure
They are voltage dependent and they are proteins
During action potential, is there polarization or depolarization of the neuron
depolarization
True or false, the action potential occurs after the threshold of exciation
True
After the threshold of excitation, does Na+ enters or leave the cell
Na+ enters the cell
Along the depolarization, how does K+ channels react
K+ channels open and make K+ leave the cell, so K+ โ outside neuron
At the peak of the depolarization, what happens to Na+ channels
How do we call that stage
Na+ channels become refractory for more Na+ to enter the cell.
This stage is called the refractory state
During the polarization of the cell, what happens to K+ channels
They remain open for K+ to LEAVE the cell
At what stage does the K+ channels closes
At the end of the repolarization when the voltage reached back the threshold of excitation
What prevents the travel of action potential in both ways
Only travels down the axons due to the Na+ channels that just opened shift to the refractory stage and can no longer open. So the the Na+ channels are numb to the accumulation of charges
What do myelinated axons allow
Saltatory signal propagation
What is the difference between myelinated axons and non-myelinated axons
Non-myelinated axons are much slower as every channel must open, whereas for myelinated axons only the channels between the node of Ranvier are active. Thus, the signal travels faster in myelinated axons
Nodes of Ranvier allow what kind of electric propagation
Saltatory signal propagation
What is the difference of electric propagation between myelinated and non-myelinated axons
Non-myelinated axons : 1 m/s
Myelinated axons : 100 m/s
How does the diameter of axon influences velocity of action potential
The greater the diameter, the fastest is the electric propagation and the higher is the sensitivity
What causes vesicles to fuse with presynaptic membrane
Influx of Ca 2+ through channels on the pre-synaptic membrane
Where do transmitter bind when released into the synaptic cleft via exocytosis
they bind to receptor molecules in the in postsynaptic membrane
What are the two effect neurotransmitter can have
An excitatory and inhibitory effect
What is the effect of an agonist drug
Agonist increase the amount of neurotransmitter in each vesicule & inhibit the reuptake of neurotransmitter
What kind of drug increases the amount of neurotransmitter in each vesicule & inhibits the reuptake of neurotransmitter
Agonist
What is the consequence when an agonist mimic a particular neurotransmitter
It can activate or increase the neurotransmitterโs effect
What is the effect of an antagonist drug
Antagonist drug decrease the release of neurotransmitter, so there is fewer in each vesicles & destroy neurotransmitters in the synapse