Neuroanatomy Flashcards
rostral
towards the front (rostrum = beak)
caudal
towards the tail
what is the encephalon?
brain
what does the CNS comprise?
brain and spinal cord
what is the rhombencephalon?
hindbrain
what is the rhombencephalon (hindbrain) divided into?
medulla oblongata
pons
cerebellum
what is medulla oblongata derived from?
myelencephalon
what is the pons derived from?
metencephalon
what is the cerebellum derived from?
metencephalon
what is the mesencephalon?
midbrain
in which part of the brain is the tectum?
midbrain
where is the tectum relative to the cerebral aqueduct in the midbrain?
dorsal
which part of the midbrain comprises of four colliculi?
tectum
what is the corpora quadrigemina?
superior and inferior colliculi
what is the cerebral peduncle?
midbrain ventral to the aqueduct
divisions of the cerebral peduncle
dorsal tegmentum
ventrally, a large fibre tract on each side of the midline - crus cerebri
what separates the tegmentum and crura?
substantia nigra
what are the crus cerebri?
large bundles of white matter emerging from the cerebral hemispheres, one on each side of the midline
pass backwards and downwards, converging to meet in the midline at the upper border of the pons
which part of the cerebral peduncles are visible on the inferior surface of the brain?
crus cerebri
what is the prosencephalon?
forebrain
divisions of the prosencephalon/ forebrain
diencephalon and telencephalon
divisions of the diencephalon
thalamus and hypothalamus
with the epi and sub-thalamus
what does the telencephalon consist of?
cerebral cortex (grey matter)
deep nuclei - basal ganglia
where are the red nuclei located?
ventral midbrain
what are the meninges?
three separate tubular sheaths of membrane which surround and enclose the ENTIRE CNS
name the meninges deep to superficial
PAD out
pia, arachnoid, dura
describe dura mater
fibrous sheet
white collagen fibres
few elastic fibres arranged in dense laminae, often of parallel fibres
latticed appearance due to wide angle between the direction of the fibres in adjacent laminae
does the spinal cord dura have an endosteal layer?
no, just cranial dura
layers of cranial dura
outer endosteal layer - equivalent to the periosteum
inner meningeal layer - dura mater proper
describe arachnoid mater
poorly vascularised membrane of loose connective tissue, consisting of collagen, elastin and reticulin fibres
loosely covers the brain without following the gyral and sulcal undulations
describe pia mater
adherent to the entire surface of the CNS, including following the gyral and sulcal folds
what is the subarachnoid space?
space between the arachnoid and pia mater containing cerebrospinal fluid
where is CSF?
in the ventricles and subarachnoid space
what is white matter?
formed by collections of nerve fibres (axons) wrapped in fatty myelin sheaths with few or no neuronal somata (cell bodies)
what is grey matter of the CNS?
formed by aggregations of neuronal cell bodies and their local processes
what is neuropil?
network of intermingled and interconnected neuronal processes which occupy the space between neuronal cell bodies in the grey matter
what are clusters of nerve cell bodies (grey matter) within the brain?
nuclei/ ganglia
e.g basal ganglia
what is the difference between ganglia and nuclei?
why is ‘basal ganglia’ a misnomer?
ganglia are clusters of nerve cell bodies in the PNS
nuclei are clusters of nerve cell bodies in the CNS
basal ganglia are in the forebrain (CNS)
what is the cortex?
outer surface of the brain
cerebral hemispheres AND cerebellum
formed by flatter sheets of neurones
what shape does the grey matter form in the spinal cord?
butterfly
difference in orientation of grey and white matter in the spinal cord and brain
brain
- grey matter surrounds white matter
spinal cord
- white matter surrounds grey matter
- grey matter forms a butterfly shape
which layer of the meninges is indistinguishable with the naked eye?
pia
arterial supply to the brain
Circle of Willis
venous drainage of the brain
cerebral veins
dural venous sinuses
in which lobe is the primary motor cortex?
frontal
in which lobe is the prefrontal cortex?
frontal
in which lobe are the primary auditory cortex and auditory association cortex?
temporal
in which lobe is Wernicke’s area?
temporal
in which lobe is the hippocampus?
temporal
in which lobe is the amygdala?
temporal
in which lobe is the primary somatosensory cortex?
parietal
in which lobe is the somatosensory association cortex?
parietal
in which lobe is the primary visual cortex?
occipital
in which lobe is the visual association cortex
occipital
function of the cerebellum
motor control of equilibrium
posture and muscle tone and movement co-ordination
where are cranial nerve nuclei?
brainstem mainly
what are gyri?
rolls of cerebral cortex
what are sulci?
grooves between the gyri
what is the central sulcus?
large fissure separating the frontal from parietal lobes
what is the lateral sulcus?
large fissure separating the temporal lobe from parietal and frontal lobes
what are the posterior most parts of the occipital lobes called?
occipital poles
what is insula?
forms the floor of the lateral sulcus
what are opercula?
means ‘lips’
the parts of the temporal, frontal and parietal lobes that overlie the insula
where is the median longitudinal fissure?
between the hemispheres
white matter connecting the hemispheres
corpus callosum
ion which lobe do the olfactory tracts run?
frontal
rounded eminences behind the optic chiasma
mamillary bodies
are the mamillary bodies visible from the dorsal or ventral surface of the brainstem?
ventral
what is the only part of the diencephalon visible on the outside of the brain?
hypothalamus
what are the crus cerebri?
part of the cerebral peduncles
two large masses of white matter emerging behind the mamillary bodies on each side, from the cerebral hemisphere
they converge as they meet the pons
bridge of neural tissue between the midbrain and the medulla oblongata
pons
what joins the hemispheres of the cerebellum?
vermis
where does the parietal lobe extend between?
central sulcus anteriorly to the imaginary parietooccipital fissure posteriorly
which lobe contains the primary sensory area?
parietal
how many of each lobe do we have?
2
which parietal lobe is usually dominant?
left
functional of the non dominant parietal lobe
visuospatial functions
function of the frontal lobe
motor function, problem solving, spontaneity, memory, language, judgement, personality, impulse control, social and sexual behaviour
where is the prefrontal cortex?
anterior part of frontal lobe
function of the prefrontal cortex
higher cognitive functions and determination of personality
where is Broca’s area?
left inferior frontal gyrus
function of Broca’s area?
language production and comprehension
where is the primary auditory complex?
temporal lobe
where is the hippocampus?
temporal lobe
in which lobe is the amygdala?
temporal
where is Wernicke’s area?
superior temporal gyrus of the left hemisphere
function of Wernicke’s area
understanding the spoken word
where is the auditory complex found?
lateral/ Sylvian fissure
where are the primary visual and visual association cortices?
occipital lobe
function of the limbic system
emotion, memory, behaviour, olfaction
function of the hippocampus
long term memory formation
function of the amygdala
motivationally significant stimuli e.g those related to reward and fear
what is the brain’s pleasure centre?
nucleus accumbens
falx cerebri
arched crescent of dura lying in the longitudinal fissure between the cerebral hemispheres
sinus at the superior border of the falx cerebri
superior saggital sinus
sinus at the free border of the falx cerebri (inferior margin)
inferior saggital sinus
thick, fibrous roof over the posterior cranial fossa and cerebellum
tentorium cerebelli
sinus within the tentorium cerebelli at its attachment to the falx cerebri (midline of the tentorium cerebelli)
straight sinus
horseshoe shaped space between the free concave border of the tentorium and the dorsum sellae of the sphenoid
tectorial inscisure
sinuses running along the line of attachment of the tentorium cerebelli to the occipital bone
transverse sinuses
sinus lying lateral to the body of the sphenoid
cavernous sinus
small, circular, horizontal fold of dura mater which forms the roof of the pituitary fossa
diaphragma sellae
dura separating the lobes of the cerebellum
falx cerebelli
compartments within the subarachnoid space where the pia mater and arachnoid membrane are not in close approximation and cerebrospinal fluid (CSF) forms pools
subarachnoid cisterns
names after their positions relative to the brain
midline communication between the 4th ventricle and subarachnoid space
foramen of magendie
lateral communication between the 4th ventricle and the subarachnoid space
foramen of luschka
which part of the meninges forms part of the blood brain barrier?
pia mater
function of the blood brain barrier
limits the ability of molecules to pass between the blood and CNS for protection
4 features of the blood brain barrier
- the edges of adjacent endothelial cells that line blood vessels are bonded closely together by tight junctions to prevent molecules passing between them
- the basement membrane of CNS blood vessels lack fenestrations
- contractile pericytes embedded in the basement membrane wrap around endothelial cells, regulating capillary blood flow, immunity and vascular permeability
- astrocyte end feet envelop CNS capillaries and restrict the flow of molecules into the CNS parenchyma
meningism
triad of headache, neck stiffness and photophobia
nausea, vomiting and fever
meningitis
inflammation of the meninges, typically caused by infection
which form of meningitis is serious?
bacterial
extradural haemorrhage
between the skull and dura mater
subdural haemorrhage
between the dura and arachnoid
which type of haemorrhage appears as a crescent on a CT scan?
subdural
subarachnoid haemorrhage
blood between the arachnoid and pia mater
which type of haemorrhage causes a sudden, severe headache?
subarachnoid
bleeding within the brain tissue
intracerebral
amaurosis fugax
temporary loss of vision to one eye
part of a carotid plaque breaks off and occludes the central retinal artery
warning of thrombus of the internal carotid artery - potential for an impending stroke
where do arteries and veins on the surface of the brain lie?
within the subarachnoid space
which arteries supply blood to the brain?
internal carotid and vertebral arteries
what percentage of blood do the vertebral arteries supply to the brain?
20%
what percentage of blood do the internal carotid arteries supply to the brain?
80%
which artery supplies the posterior cerebrum and posterior cranial fossa?
vertebral
which artery supplies the anterior and middle cerebrum and diencephalon?
internal carotid
what pathology commonly affects the cerebral arteries?
berry aneurysms
draw and label the circle of Willis
.
where does the internal carotid arise?
bifurcation of the common carotid at the level of the upper border of the thyroid cartilage
which bone does the internal carotid enter?
temporal
where does the internal carotid divide into its terminal branches?
anterior perforated substance at the medial end of the lateral sulcus
what are the terminal branches of the internal carotid artery?
anterior and middle cerebral arteries
which artery supplies the corpus callosum and medial aspects of the hemispheres?
anterior cerebral artery
which is the largest terminal branch of the internal carotid?
middle cerebral artery
which artery supplies the lateral surface of the hemisphere and the deep structures of the anterior part of the cerebral hemisphere?
middle cerebral artery
what connects the two anterior cerebral arteries?
anterior communicating artery
what connects the internal carotid and vertebro-basilar systems?
posterior communicating artery
which artery supplies the occipital lobe?
posterior cerebral artery
which foramen does the opthalmic artery pass through?
optic canal
which foramen do the ethmoidal artery and vein pass through?
ethmoidal foramen
which foramen does the superior ophthalmic vein pass through?
superior orbital fissure
which foramen does the middle meningeal artery pass through?
foramen spinosum
which foramen does the internal jugular vein pass through?
jugular foramen
which foramen do the vertebral arteries pass through?
foramen magnum
which foramen does the labyrinthine artery pass through?
internal acoustic meatus
is there a functional anastomosis between the anterior and posterior circulations?
no
where do the vertebral arteries arise from?
subclavian artery
where do the vertebral arteries unite, and what do they form?
lower border of the pons
basilar artery
where does the basilar artery lie?
anterior median fissure on the pons
which vessels form the posterior circulation?
vertebral and basilar arteries and branches
posterior cerebral artery
what connects the anterior and posterior circulations?
circle of willis
where are berry aneurysms most likely to form?
anterior communicating artery which lies in the subarachnoid space
types of stroke
ischaemic or haemorrhagic
lasts over 24h (under = TIA)
blood supply to the brain is interrupted
where do cerebral veins drain into?
dural venous sinuses
what are internal cerebral veins?
run within the substance of the brain tissue and end when they reach the surface of the brain where they become external cerebral veins
what are external cerebral veins?
run on the surface of the brain, crossing the subarachnoid space to drain into the dural venous sinuses
which vein drains the deep structures of the brain?
great cerebral vein of Galen
where does the great cerebral vein (of Galen) drain into?
straight sinus
draw and label the dural venous sinuses
.
where do ALL the dural venous sinuses drain into?
internal jugular veins
a deep groove in the mastoid portion of the temporal bone
sigmoid sinus
sinus beside the body of the sphenoid bone
cavernous sinus
what does the cavernous sinus contain?
five cranial nerves and the internal carotid artery
carotid plexus
cranial nerves
- abducens
- oculomotor nerve
- trochlear
first and second divisions of the trigeminal
3rd, 4th, first and second divisions of the 5th, 6th
sinus in the groove between the petrous temporal bone and the basal part of the occipital bone
inferior petrosal sinus
emissary veins
allow communication between inter cranial venous sinuses and the veins outside the skull
consequences of venous sinus thrombosis
cerebral oedema and raised inter cranial pressure
brain damage
headaches, epileptic seizures, focal motor deficit, deterioration in consciousness
what are arachnoid granulations?
arachnoid granulations are pockets of arachnoid membrane and subarachnoid space which connect cerebrospinal fluid to venous circulation
what does the brain develop from?
hollow neural tube
where is most choroid plexus found?
lateral ventricles
what is choroid plexus and what is its function?
a network of blood vessels in each ventricle of the brain, producing the cerebrospinal fluid
what connects the lateral and second ventricle?
inter ventricular foramen of Munroe
what connects the third and fourth ventricle?
cerebral aqueduct
from the fourth ventricle, which foramina does CSF then travel to?
median foramen of magendie
lateral foramen of luschka
which cells line the ventricles?
ependymal cells
what constitutes the CSF-brain barrier?
the ependyma
which blood vessels supply the deep structures of the anterior part of the cerebral hemisphere?
anterior perforating branches
name the cranial fossae
anterior, middle and posterior
in which bone is the cribriform plate?
ethmoid
in which fossa is the frontal lobe contained?
anterior cranial fossa
which bones form the anterior cranial fossa?
frontal bone, ethmoid bone and sphenoid bone
what is the crista galli?
midline projection in the ethmoid bone
which wing of the sphenoid bone bounds the anterior cranial fossa posteriorly?
lesser
which lobes of the brain are contained in the middle cranial fossa?
temporal, parietal and occipital
list the cranial fossae in order from shallowest to deepest
anterior, middle, posterior
which fissure is between the greater and lesser wings of the sphenoid?
superior orbital fissure
in which bone is the optic canal?
sphenoid
which bones form the middle cranial fossa
sphenoid and two temporal bones
what is the sella turcica?
saddle-like bony formation on the upper surface of the body of sphenoid bone
houses the pituitary gland
also called the pituitary (hypophyseal) fossa
in which cranial fossa is the foramen rotundum?
middle
in which cranial fossa is the foramen ovale?
middle
in which cranial fossa is the foramen lacerum?
middle
in which cranial fossa is the foramen spinosum?
middle
what does the posterior cranial fossa contain?
cerebellum, pons and medulla oblongata
in which cranial fossa is the foramen magnum?
posterior
in which cranial fossa is the hypoglossal canal?
posterior
in which cranial fossa is the internal acoustic meatus (internal auditory meatus)?
posterior