Neuro Section 6- Part 2

Question 1

In brain capillaries, passage through intracellular clefts is blocked by ______ junctions, and exchange of blood solutes is highly _________

Answer 1

Tight
Selective

Question 2

What is found in all areas of the brain parenchyma?

Answer 2

BBB

Question 3

What parts of the brain is BBB NOT found?

Answer 3

Hypothalamus, pineal gland, postrema

Question 4

What has an endothelium surrounded by pericytes and Astrocytes?

Answer 4

BBB

Question 5

What barrier can small, uncharged, lipid soluble, and unbound plasma proteins easily pass cross?

Answer 5

BBB capillary endothelium

Question 6

If a molecule is not small, uncharted, lipid soluble or unbound to plasma proteins, how do they cross the BBB?

Answer 6

Specific carrier-mediated transport mechanisms

Question 7

What is Pgp an example of?

Answer 7

Transport system at the BBB

Question 8

What does Pgp include?

Answer 8

MDR’s (multi drug resistance protein)

Question 9

What is the transport system for glucose (GLUT) an example of?

Answer 9

Transport system at the BBB

Question 10

Effluent pump Pgp:
What does the BBB do to many antibiotics, antiparastic drugs, and potentially harmful substances?

Answer 10

Repeal them so they never reach the nervous tissue

Question 11

What are organic cations, weak organic bases, organic anions, peptides, many commonly used drugs examples of?

Answer 11

Substrates of BBB

Question 12

What is a protective system against external harmful substances, poisons, and medicaments?

Answer 12

MDR 1

Question 13

What normal tissues are the BBB expressed in?

Answer 13

Adrenal cortex, kidney, testes, intestines, liver